PRAG1 (PEAK1 related, kinase-activating pseudokinase 1)

2017-01-01  

Identity

HGNC
PRAG1
LOCATION
8p23.1
LOCUSID
157285
ALIAS
NACK,PEAK2,PRAGMIN,SGK223

Other Information

Locus ID:

NCBI: 157285
MIM: 617344
HGNC: 25438
Ensembl: ENSG00000275342

Variants:

dbSNP: 157285
ClinVar: 157285
TCGA: ENSG00000275342
COSMIC: PRAG1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000275342ENST00000615670Q86YV5
ENSG00000275342ENST00000622241Q86YV5

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
124712432002The protein kinase complement of the human genome.2088
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
164813212006Pragmin, a novel effector of Rnd2 GTPase, stimulates RhoA activity.27
218732242011Mammalian Pragmin regulates Src family kinases via the Glu-Pro-Ile-Tyr-Ala (EPIYA) motif that is exploited by bacterial effectors.18
262156342015The pseudokinase SgK223 promotes invasion of pancreatic ductal epithelial cells through JAK1/Stat3 signaling.15
295030742018Dimerization of the Pragmin Pseudo-Kinase Regulates Protein Tyrosine Phosphorylation.9
267822862016Silencing NACK by siRNA inhibits tumorigenesis in non-small cell lung cancer via targeting Notch1 signaling pathway.8
271167012016C-terminal Src kinase-mediated EPIYA phosphorylation of Pragmin creates a feed-forward C-terminal Src kinase activation loop that promotes cell motility.8
275317442016Homo- and Heterotypic Association Regulates Signaling by the SgK269/PEAK1 and SgK223 Pseudokinases.7
290798502017Structure of SgK223 pseudokinase reveals novel mechanisms of homotypic and heterotypic association.6

Citation

Dessen P

PRAG1 (PEAK1 related, kinase-activating pseudokinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2017-01-01

Online version: http://atlasgeneticsoncology.org/gene/56711/prag1