PRAM1 (PML-RARA regulated adaptor molecule 1)

2003-02-01  

Identity

HGNC
PRAM1
LOCATION
19p13.2
LOCUSID
84106
ALIAS
PML-RAR,PRAM-1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84106
MIM: 606466
HGNC: 30091
Ensembl: ENSG00000133246

Variants:

dbSNP: 84106
ClinVar: 84106
TCGA: ENSG00000133246
COSMIC: PRAM1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133246ENST00000423345Q96QH2
ENSG00000133246ENST00000600262M0R149

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
191092272009Hidden abnormalities and novel classification of t(15;17) acute promyelocytic leukemia (APL) based on genomic alterations.22
251267242014MIR125B1 represses the degradation of the PML-RARA oncoprotein by an autophagy-lysosomal pathway in acute promyelocytic leukemia.16
216735162011PML-RARα enhances constitutive autophagic activity through inhibiting the Akt/mTOR pathway.15
155726932004PRAM-1 is required for optimal integrin-dependent neutrophil function.12
259446862015Absolute quantification of the pretreatment PML-RARA transcript defines the relapse risk in acute promyelocytic leukemia.10
168314442006Lipid-binding hSH3 domains in immune cell adapter proteins.8
156370622005PRAM-1 potentiates arsenic trioxide-induced JNK activation.4
165025822006Diagnosis and monitoring of PML-RARalpha-positive acute promyelocytic leukemia by quantitative RT-PCR.2
196236542009Quantitative detection of PML-RARalpha fusion transcript by real-time PCR with a single primer pair.2
283178332017Regulation of NF-κB by PML and PML-RARα.2

Citation

Dessen P

PRAM1 (PML-RARA regulated adaptor molecule 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41827/pram1