Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PRB3 (proline rich protein BstNI subfamily 3)

Identity

Alias_symbol (synonym)PRG
Other aliasG1
HGNC (Hugo) PRB3
LocusID (NCBI) 5544
Atlas_Id 54869
Location 12p13.2  [Link to chromosome band 12p13]
Location_base_pair Starts at 11265914 and ends at 11269707 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BCAT1 (12p12.1) / PRB3 (12p13.2)BCAT1 12p12.1 / PRB3 12p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(12;12)(p12;p13) BCAT1/PRB3

External links

Nomenclature
HGNC (Hugo)PRB3   9339
Cards
Entrez_Gene (NCBI)PRB3  5544  proline rich protein BstNI subfamily 3
AliasesG1; PRG
GeneCards (Weizmann)PRB3
Ensembl hg19 (Hinxton)ENSG00000197870 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000197870 [Gene_View]  ENSG00000197870 [Sequence]  chr12:11265914-11269707 [Contig_View]  PRB3 [Vega]
ICGC DataPortalENSG00000197870
TCGA cBioPortalPRB3
AceView (NCBI)PRB3
Genatlas (Paris)PRB3
WikiGenes5544
SOURCE (Princeton)PRB3
Genetics Home Reference (NIH)PRB3
Genomic and cartography
GoldenPath hg38 (UCSC)PRB3  -     chr12:11265914-11269707 -  12p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRB3  -     12p13.2   [Description]    (hg19-Feb_2009)
GoldenPathPRB3 - 12p13.2 [CytoView hg19]  PRB3 - 12p13.2 [CytoView hg38]
ImmunoBaseENSG00000197870
Mapping of homologs : NCBIPRB3 [Mapview hg19]  PRB3 [Mapview hg38]
OMIM168840   
Gene and transcription
Genbank (Entrez)AA376677 AA376715 BC096209 BC096210 BC096211
RefSeq transcript (Entrez)NM_006249
RefSeq genomic (Entrez)NC_000012 NG_013305 NT_187658
Consensus coding sequences : CCDS (NCBI)PRB3
Cluster EST : UnigeneHs.73031 [ NCBI ]
CGAP (NCI)Hs.73031
Alternative Splicing GalleryENSG00000197870
Gene ExpressionPRB3 [ NCBI-GEO ]   PRB3 [ EBI - ARRAY_EXPRESS ]   PRB3 [ SEEK ]   PRB3 [ MEM ]
Gene Expression Viewer (FireBrowse)PRB3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5544
GTEX Portal (Tissue expression)PRB3
Human Protein AtlasENSG00000197870-PRB3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ04118   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ04118  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ04118
Splice isoforms : SwissVarQ04118
PhosPhoSitePlusQ04118
Domains : Interpro (EBI)Pro-rich   
Domain families : Pfam (Sanger)Pro-rich (PF15240)   
Domain families : Pfam (NCBI)pfam15240   
Domain families : Smart (EMBL)Pro-rich (SM01412)  
Conserved Domain (NCBI)PRB3
DMDM Disease mutations5544
Blocks (Seattle)PRB3
SuperfamilyQ04118
Human Protein Atlas [tissue]ENSG00000197870-PRB3 [tissue]
Peptide AtlasQ04118
HPRD01352
IPIIPI00006699   IPI00883885   IPI00953131   
Protein Interaction databases
DIP (DOE-UCLA)Q04118
IntAct (EBI)Q04118
FunCoupENSG00000197870
BioGRIDPRB3
STRING (EMBL)PRB3
ZODIACPRB3
Ontologies - Pathways
QuickGOQ04118
Ontology : AmiGOextracellular region  biological_process  defense response to Gram-negative bacterium  
Ontology : EGO-EBIextracellular region  biological_process  defense response to Gram-negative bacterium  
NDEx NetworkPRB3
Atlas of Cancer Signalling NetworkPRB3
Wikipedia pathwaysPRB3
Orthology - Evolution
OrthoDB5544
GeneTree (enSembl)ENSG00000197870
Phylogenetic Trees/Animal Genes : TreeFamPRB3
HOGENOMQ04118
Homologs : HomoloGenePRB3
Homology/Alignments : Family Browser (UCSC)PRB3
Gene fusions - Rearrangements
Fusion : MitelmanBCAT1/PRB3 [12p12.1/12p13.2]  [t(12;12)(p12;p13)]  
Fusion PortalBCAT1 12p12.1 PRB3 12p13.2 OV
Fusion : QuiverPRB3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRB3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRB3
dbVarPRB3
ClinVarPRB3
1000_GenomesPRB3 
Exome Variant ServerPRB3
ExAC (Exome Aggregation Consortium)ENSG00000197870
GNOMAD BrowserENSG00000197870
Varsome BrowserPRB3
Genetic variants : HAPMAP5544
Genomic Variants (DGV)PRB3 [DGVbeta]
DECIPHERPRB3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRB3 
Mutations
ICGC Data PortalPRB3 
TCGA Data PortalPRB3 
Broad Tumor PortalPRB3
OASIS PortalPRB3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRB3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPRB3
Mutations and Diseases : HGMDPRB3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRB3
DgiDB (Drug Gene Interaction Database)PRB3
DoCM (Curated mutations)PRB3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRB3 (select a term)
intoGenPRB3
Cancer3DPRB3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM168840   
Orphanet
DisGeNETPRB3
MedgenPRB3
Genetic Testing Registry PRB3
NextProtQ04118 [Medical]
TSGene5544
GENETestsPRB3
Target ValidationPRB3
Huge Navigator PRB3 [HugePedia]
snp3D : Map Gene to Disease5544
BioCentury BCIQPRB3
ClinGenPRB3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5544
Chemical/Pharm GKB GenePA33701
Clinical trialPRB3
Miscellaneous
canSAR (ICR)PRB3 (select the gene name)
DataMed IndexPRB3
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRB3
EVEXPRB3
GoPubMedPRB3
iHOPPRB3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 18:02:24 CET 2019
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