PRC1 (protein regulator of cytokinesis 1)

2003-08-01  

Identity

HGNC
PRC1
LOCATION
15q26.1
LOCUSID
9055
ALIAS
ASE1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9055
MIM: 603484
HGNC: 9341
Ensembl: ENSG00000198901

Variants:

dbSNP: 9055
ClinVar: 9055
TCGA: ENSG00000198901
COSMIC: PRC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198901ENST00000361188O43663
ENSG00000198901ENST00000394249O43663
ENSG00000198901ENST00000442656O43663
ENSG00000198901ENST00000555455G3V3N7
ENSG00000198901ENST00000556972H3BSJ8
ENSG00000198901ENST00000557905H0YM42
ENSG00000198901ENST00000559811H0YLA0
ENSG00000198901ENST00000559828H0YL53
ENSG00000198901ENST00000560423H0YNE4

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases activate CITREACTOMER-HSA-5625900

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
196093472009A genome-wide association study of hypertension and blood pressure in African Americans.185
120820782002PRC1 is a microtubule binding and bundling protein essential to maintain the mitotic spindle midzone.158
152978752004Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation.120
156251052005Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis.111
173516402007Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1.111
194683002009Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation.104
206919022010Insights into antiparallel microtubule crosslinking by PRC1, a conserved nonmotor microtubule binding protein.104
164319292006KIF14 and citron kinase act together to promote efficient cytokinesis.99
208898532011Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.65
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62

Citation

Dessen P

PRC1 (protein regulator of cytokinesis 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41829/prc1