PRCP (prolylcarboxypeptidase)

2011-03-01  

Identity

HGNC
PRCP
LOCATION
11q14.1
LOCUSID
5547
ALIAS
HUMPCP,PCP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5547
MIM: 176785
HGNC: 9344
Ensembl: ENSG00000137509

Variants:

dbSNP: 5547
ClinVar: 5547
TCGA: ENSG00000137509
COSMIC: PRCP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137509ENST00000313010P42785
ENSG00000137509ENST00000313010A0A024R5L0
ENSG00000137509ENST00000393399P42785
ENSG00000137509ENST00000527444E9PQN3
ENSG00000137509ENST00000528082E9PLY4
ENSG00000137509ENST00000529671E9PNJ1
ENSG00000137509ENST00000531128E9PL85
ENSG00000137509ENST00000531801E9PIG4
ENSG00000137509ENST00000532809E9PNF7
ENSG00000137509ENST00000533126E9PL49
ENSG00000137509ENST00000534264E9PR42
ENSG00000137509ENST00000534396E9PQB5
ENSG00000137509ENST00000534631E9PKN6

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Renin-angiotensin systemKEGGko04614
Renin-angiotensin systemKEGGhsa04614
Protein digestion and absorptionKEGGko04974
Protein digestion and absorptionKEGGhsa04974
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
HemostasisREACTOMER-HSA-109582
Formation of Fibrin Clot (Clotting Cascade)REACTOMER-HSA-140877
Intrinsic Pathway of Fibrin Clot FormationREACTOMER-HSA-140837
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA444552HypertensionDiseaseClinicalAnnotationassociatedPD20079160
PA448561benazeprilChemicalClinicalAnnotationassociatedPD20079160

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
118305812002Identification and characterization of prolylcarboxypeptidase as an endothelial cell prekallikrein activator.58
149967002004Recombinant prolylcarboxypeptidase activates plasma prekallikrein.41
237445842013Prolylcarboxypeptidase promotes angiogenesis and vascular repair.19
183964402009Prolylcarboxypeptidase: a cardioprotective enzyme.18
166819912006Prolylcarboxypeptidase gene, chronic hypertension, and risk of preeclampsia.17
166819912006Prolylcarboxypeptidase gene, chronic hypertension, and risk of preeclampsia.17
121238262002Identification of prolylcarboxypeptidase as the cell matrix-associated prekallikrein activator.15
205407602010Structural definition and substrate specificity of the S28 protease family: the crystal structure of human prolylcarboxypeptidase.15
200791602009E112D polymorphism in the prolylcarboxypeptidase gene is associated with blood pressure response to benazepril in Chinese hypertensive patients.11

Citation

Dessen P

PRCP (prolylcarboxypeptidase)

Atlas Genet Cytogenet Oncol Haematol. 2011-03-01

Online version: http://atlasgeneticsoncology.org/gene/52116/prcp