PRDM14 (PR/SET domain 14)

2007-12-01  

Identity

HGNC
PRDM14
LOCATION
8q13.3
LOCUSID
63978
ALIAS
PFM11

Other Information

Locus ID:

NCBI: 63978
MIM: 611781
HGNC: 14001
Ensembl: ENSG00000147596

Variants:

dbSNP: 63978
ClinVar: 63978
TCGA: ENSG00000147596
COSMIC: PRDM14

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147596ENST00000276594Q9GZV8
ENSG00000147596ENST00000426346C9JMM8

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
Transcriptional regulation of pluripotent stem cellsREACTOMER-HSA-452723

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
209531722010A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity.201
179428942007Gene amplification and overexpression of PRDM14 in breast cancers.40
181946692008PRDM14 suppresses expression of differentiation marker genes in human embryonic stem cells.35
257502082015Human primordial germ cell commitment in vitro associates with a unique PRDM14 expression profile.30
232806022013A PRC2-dependent repressive role of PRDM14 in human embryonic stem cells and induced pluripotent stem cell reprogramming.27
236902692013High expression of PRDM14 correlates with cell differentiation and is a novel prognostic marker in resected non-small cell lung cancer.16
252339272014Methylation-mediated repression of PRDM14 contributes to apoptosis evasion in HPV-positive cancers.15
284988962017Inhibition of PRDM14 expression in pancreatic cancer suppresses cancer stem-like properties and liver metastasis in mice.13
284233532017Silencing PRDM14 expression by an innovative RNAi therapy inhibits stemness, tumorigenicity, and metastasis of breast cancer.9
290249362017Glucose insult elicits hyperactivation of cancer stem cells through miR-424-cdc42-prdm14 signalling axis.6

Citation

Dessen P

PRDM14 (PR/SET domain 14)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49924/prdm14