PRDM5 (PR/SET domain 5)

2003-05-01  

Identity

HGNC
LOCATION
4q27
LOCUSID
ALIAS
BCS2,PFM2
FUSION GENES

Other Information

Locus ID:

NCBI: 11107
MIM: 614161
HGNC: 9349
Ensembl: ENSG00000138738

Variants:

dbSNP: 11107
ClinVar: 11107
TCGA: ENSG00000138738
COSMIC: PRDM5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138738ENST00000264808Q9NQX1
ENSG00000138738ENST00000394435Q9NQX1
ENSG00000138738ENST00000428209Q9NQX1
ENSG00000138738ENST00000502409H0Y9S1
ENSG00000138738ENST00000515109Q9NQX1

Expression (GTEx)

0
5
10
15

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
150771632004PRDM5 is silenced in human cancers and has growth suppressive activities.38
216649992011Mutations in PRDM5 in brittle cornea syndrome identify a pathway regulating extracellular matrix development and maintenance.34
176360192007Epigenetic regulation of protein-coding and microRNA genes by the Gfi1-interacting tumor suppressor PRDM5.31
176998562007PRDM5 identified as a target of epigenetic silencing in colorectal and gastric cancer.30
220872972011The epigenetic modifier PRDM5 functions as a tumor suppressor through modulating WNT/β-catenin signaling and is frequently silenced in multiple tumors.25
249669402014Methylation of PRDM2, PRDM5 and PRDM16 genes in lung cancer cells.16
238730262014Prdm5 suppresses Apc(Min)-driven intestinal adenomas and regulates monoacylglycerol lipase expression.11
264899292016Whole exome sequencing identifies a heterozygous missense variant in the PRDM5 gene in a family with Axenfeld-Rieger syndrome.11
203320992010A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.8

Citation

Dessen P

PRDM5 (PR/SET domain 5)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41836/prdm5