PRDX3 (peroxiredoxin 3)

2007-02-01  

Identity

HGNC
PRDX3
LOCATION
10q26.11
LOCUSID
10935
ALIAS
AOP-1,AOP1,HBC189,MER5,PRO1748,SP-22,prx-III
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10935
MIM: 604769
HGNC: 9354
Ensembl: ENSG00000165672

Variants:

dbSNP: 10935
ClinVar: 10935
TCGA: ENSG00000165672
COSMIC: PRDX3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165672ENST00000298510P30048
ENSG00000165672ENST00000298510A0A384MTR2

Expression (GTEx)

0
100
200
300
400
500
600
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cellular responses to stressREACTOMER-HSA-2262752
Detoxification of Reactive Oxygen SpeciesREACTOMER-HSA-3299685

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
152803822004Peroxiredoxin III, a mitochondrion-specific peroxidase, regulates apoptotic signaling by mitochondria.123
119042902002Proteomics analysis of cellular response to oxidative stress. Evidence for in vivo overoxidation of peroxiredoxins at their active site.88
126509762003Aberrant expression of peroxiredoxin subtypes in neurodegenerative disorders.77
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
175480472007Mitochondrial thioredoxin-2/peroxiredoxin-3 system functions in parallel with mitochondrial GSH system in protection against oxidative stress.60
120114292002The c-Myc target gene PRDX3 is required for mitochondrial homeostasis and neoplastic transformation.54
187784102008Reduction of mitochondrial H2O2 by overexpressing peroxiredoxin 3 improves glucose tolerance in mice.54
117717462001Protein levels of human peroxiredoxin subtypes in brains of patients with Alzheimer's disease and Down syndrome.48
181950032008FOXO3A regulates peroxiredoxin III expression in human cardiac fibroblasts.45
183785752008Decreased expression of peroxiredoxins in Fuchs' endothelial dystrophy.44

Citation

Dessen P

PRDX3 (peroxiredoxin 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45771/prdx3