PRDX5 (peroxiredoxin 5)

2007-02-01  

Identity

HGNC
LOCATION
11q13.1
LOCUSID
ALIAS
ACR1,AOEB166,B166,HEL-S-55,PLP,PMP20,PRDX6,PRXV,SBBI10,prx-V
FUSION GENES

Other Information

Locus ID:

NCBI: 25824
MIM: 606583
HGNC: 9355
Ensembl: ENSG00000126432

Variants:

dbSNP: 25824
ClinVar: 25824
TCGA: ENSG00000126432
COSMIC: PRDX5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000126432ENST00000265462P30044
ENSG00000126432ENST00000347941P30044
ENSG00000126432ENST00000352435P30044

Expression (GTEx)

0
100
200
300
400
500
600
700

Pathways

PathwaySourceExternal ID
PeroxisomeKEGGko04146
PeroxisomeKEGGhsa04146
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Metabolic GenesREACTOMER-HSA-5628897
Cellular responses to stressREACTOMER-HSA-2262752
Detoxification of Reactive Oxygen SpeciesREACTOMER-HSA-3299685

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
205960222010Genome-wide association study in alopecia areata implicates both innate and adaptive immunity.146
152800352004Human peroxiredoxin 5 is a peroxynitrite reductase.50
183785752008Decreased expression of peroxiredoxins in Fuchs' endothelial dystrophy.44
178928562007Pre-steady state kinetic characterization of human peroxiredoxin 5: taking advantage of Trp84 fluorescence increase upon oxidation.42
118324872002Glutaredoxin-dependent peroxiredoxin from poplar: protein-protein interaction and catalytic mechanism.41
115185282001Crystal structure of human peroxiredoxin 5, a novel type of mammalian peroxiredoxin at 1.5 A resolution.36
158481672005Human mitochondrial peroxiredoxin 5 protects from mitochondrial DNA damages induced by hydrogen peroxide.36
176013502007A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.27
193364752009Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk.27
182623542008Silencing of peroxiredoxin 3 and peroxiredoxin 5 reveals the role of mitochondrial peroxiredoxins in the protection of human neuroblastoma SH-SY5Y cells toward MPP+.25

Citation

Dessen P

PRDX5 (peroxiredoxin 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46272/prdx5