PREX1 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1)
2006-10-01 Affiliation
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 57580
MIM: 606905
HGNC: 32594
Ensembl: ENSG00000124126
Variants:
dbSNP: 57580
ClinVar: 57580
TCGA: ENSG00000124126
COSMIC: PREX1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000124126 | ENST00000371941 | Q8TCU6 |
| ENSG00000124126 | ENST00000482556 | H0YDZ4 |
| ENSG00000124126 | ENST00000620554 | A0A087WY11 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38329813 | 2024 | PREX1 improves homeostatic proliferation to maintain a naive CD4+ T cell compartment in older age. | 0 |
| 38329813 | 2024 | PREX1 improves homeostatic proliferation to maintain a naive CD4+ T cell compartment in older age. | 0 |
| 37434402 | 2023 | Silencing Rac1 and Prex1 Inhibit Epithelial-Mesenchymal Transition in Human Gastric Cancer Cells Induced by Transforming Growth Factor-β1. | 1 |
| 37434402 | 2023 | Silencing Rac1 and Prex1 Inhibit Epithelial-Mesenchymal Transition in Human Gastric Cancer Cells Induced by Transforming Growth Factor-β1. | 1 |
| 35864164 | 2022 | Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism. | 4 |
| 35864164 | 2022 | Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism. | 4 |
| 33412417 | 2021 | Gβγ recruits and activates P-Rex1 via two independent binding interfaces. | 3 |
| 34624316 | 2021 | Identification of Rac guanine nucleotide exchange factors promoting Lgl1 phosphorylation in glioblastoma. | 0 |
| 33412417 | 2021 | Gβγ recruits and activates P-Rex1 via two independent binding interfaces. | 3 |
| 34624316 | 2021 | Identification of Rac guanine nucleotide exchange factors promoting Lgl1 phosphorylation in glioblastoma. | 0 |
| 31636389 | 2020 | PREX1 drives spontaneous bone dissemination of ER+ breast cancer cells. | 15 |
| 32661198 | 2020 | The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity and contributes to membrane binding. | 5 |
| 32785873 | 2020 | Overexpression of PREX1 in oral squamous cell carcinoma indicates poor prognosis. | 3 |
| 31636389 | 2020 | PREX1 drives spontaneous bone dissemination of ER+ breast cancer cells. | 15 |
| 32661198 | 2020 | The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity and contributes to membrane binding. | 5 |
Citation
Dessen P
PREX1 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43426/prex1
