PREX1 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1)

2006-10-01 Affiliation

Identity

HGNC

PREX1

LOCATION

20q13.13

LOCUSID

57580

ALIAS

P-REX1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 57580
MIM: 606905
HGNC: 32594
Ensembl: ENSG00000124126

Variants:

dbSNP: 57580
ClinVar: 57580
TCGA: ENSG00000124126
COSMIC: PREX1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000124126	ENST00000371941	Q8TCU6
ENSG00000124126	ENST00000482556	H0YDZ4
ENSG00000124126	ENST00000620554	A0A087WY11

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Chemokine signaling pathway	KEGG	ko04062
Chemokine signaling pathway	KEGG	hsa04062
Signal Transduction	REACTOME	R-HSA-162582
Signalling by NGF	REACTOME	R-HSA-166520
p75 NTR receptor-mediated signalling	REACTOME	R-HSA-193704
Cell death signalling via NRAGE, NRIF and NADE	REACTOME	R-HSA-204998
NRAGE signals death through JNK	REACTOME	R-HSA-193648
Signaling by Rho GTPases	REACTOME	R-HSA-194315
Rho GTPase cycle	REACTOME	R-HSA-194840
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (12/13) signalling events	REACTOME	R-HSA-416482

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
11955434	2002	P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac.	193
21172654	2010	Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.	95
17565979	2007	P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration.	72
19305425	2009	Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis.	71
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
21042280	2011	P-Rex1 participates in Neuregulin-ErbB signal transduction and its expression correlates with patient outcome in breast cancer.	52
21339740	2011	Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis.	49
17698854	2007	Membrane translocation of P-Rex1 is mediated by G protein betagamma subunits and phosphoinositide 3-kinase.	44
15545267	2005	Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunits.	43
17227822	2007	Signaling requirements for translocation of P-Rex1, a key Rac2 exchange factor involved in chemoattractant-stimulated human neutrophil function.	31

Citation

Dessen P

PREX1 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43426/prex1