PRKACA (protein kinase cAMP-activated catalytic subunit alpha)

2003-11-01 Affiliation

Identity

HGNC

PRKACA

LOCATION

19p13.12

LOCUSID

5566

ALIAS

CAFD1,PKACA,PPNAD4

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5566
MIM: 601639
HGNC: 9380
Ensembl: ENSG00000072062

Variants:

dbSNP: 5566
ClinVar: 5566
TCGA: ENSG00000072062
COSMIC: PRKACA

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000072062	ENST00000308677	P17612
ENSG00000072062	ENST00000308677	A0A024R7J0
ENSG00000072062	ENST00000587372	K7ERP6
ENSG00000072062	ENST00000589284	K7EMV1
ENSG00000072062	ENST00000589994	P17612
ENSG00000072062	ENST00000590853	K7ENJ5
ENSG00000072062	ENST00000593092	Q15136

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
MAPK signaling pathway	KEGG	ko04010
Calcium signaling pathway	KEGG	ko04020
Autophagy - animal	KEGG	ko04140
Wnt signaling pathway	KEGG	ko04310
Hedgehog signaling pathway	KEGG	ko04340
Tight junction	KEGG	ko04530
Gap junction	KEGG	ko04540
Long-term potentiation	KEGG	ko04720
Olfactory transduction	KEGG	ko04740
Taste transduction	KEGG	ko04742
Insulin signaling pathway	KEGG	ko04910
GnRH signaling pathway	KEGG	ko04912
Progesterone-mediated oocyte maturation	KEGG	ko04914
Melanogenesis	KEGG	ko04916
Vibrio cholerae infection	KEGG	ko05110
MAPK signaling pathway	KEGG	hsa04010
Calcium signaling pathway	KEGG	hsa04020
Autophagy - animal	KEGG	hsa04140
Wnt signaling pathway	KEGG	hsa04310
Hedgehog signaling pathway	KEGG	hsa04340
Tight junction	KEGG	hsa04530
Gap junction	KEGG	hsa04540
Long-term potentiation	KEGG	hsa04720
Olfactory transduction	KEGG	hsa04740
Taste transduction	KEGG	hsa04742
Insulin signaling pathway	KEGG	hsa04910
GnRH signaling pathway	KEGG	hsa04912
Melanogenesis	KEGG	hsa04916
Parkinson's disease	KEGG	hsa05012
Vibrio cholerae infection	KEGG	hsa05110
Pathways in cancer	KEGG	hsa05200
Vascular smooth muscle contraction	KEGG	hsa04270
Chemokine signaling pathway	KEGG	ko04062
Vascular smooth muscle contraction	KEGG	ko04270
Chemokine signaling pathway	KEGG	hsa04062
Prion diseases	KEGG	ko05020
Prion diseases	KEGG	hsa05020
Progesterone-mediated oocyte maturation	KEGG	hsa04914
Dilated cardiomyopathy	KEGG	ko05414
Dilated cardiomyopathy	KEGG	hsa05414
Oocyte meiosis	KEGG	ko04114
Oocyte meiosis	KEGG	hsa04114
Vasopressin-regulated water reabsorption	KEGG	ko04962
Vasopressin-regulated water reabsorption	KEGG	hsa04962
Salivary secretion	KEGG	ko04970
Salivary secretion	KEGG	hsa04970
Gastric acid secretion	KEGG	ko04971
Gastric acid secretion	KEGG	hsa04971
Amoebiasis	KEGG	ko05146
Amoebiasis	KEGG	hsa05146
Bile secretion	KEGG	ko04976
Bile secretion	KEGG	hsa04976
Endocrine and other factor-regulated calcium reabsorption	KEGG	ko04961
Endocrine and other factor-regulated calcium reabsorption	KEGG	hsa04961
Glutamatergic synapse	KEGG	ko04724
Glutamatergic synapse	KEGG	hsa04724
Cholinergic synapse	KEGG	hsa04725
HTLV-I infection	KEGG	ko05166
HTLV-I infection	KEGG	hsa05166
GABAergic synapse	KEGG	ko04727
GABAergic synapse	KEGG	hsa04727
Dopaminergic synapse	KEGG	ko04728
Dopaminergic synapse	KEGG	hsa04728
Serotonergic synapse	KEGG	hsa04726
Retrograde endocannabinoid signaling	KEGG	hsa04723
Retrograde endocannabinoid signaling	KEGG	ko04723
Cocaine addiction	KEGG	hsa05030
Cocaine addiction	KEGG	ko05030
Amphetamine addiction	KEGG	hsa05031
Amphetamine addiction	KEGG	ko05031
Morphine addiction	KEGG	hsa05032
Morphine addiction	KEGG	ko05032
Epstein-Barr virus infection	KEGG	hsa05169
Alcoholism	KEGG	hsa05034
Epstein-Barr virus infection	KEGG	ko05169
Alcoholism	KEGG	ko05034
Viral carcinogenesis	KEGG	hsa05203
Viral carcinogenesis	KEGG	ko05203
Circadian entrainment	KEGG	hsa04713
Circadian entrainment	KEGG	ko04713
Insulin secretion	KEGG	hsa04911
Proteoglycans in cancer	KEGG	hsa05205
Proteoglycans in cancer	KEGG	ko05205
Ovarian steroidogenesis	KEGG	hsa04913
Ovarian steroidogenesis	KEGG	ko04913
Estrogen signaling pathway	KEGG	hsa04915
Estrogen signaling pathway	KEGG	ko04915
Thyroid hormone synthesis	KEGG	hsa04918
Thyroid hormone synthesis	KEGG	ko04918
Ras signaling pathway	KEGG	hsa04014
Adrenergic signaling in cardiomyocytes	KEGG	hsa04261
Adrenergic signaling in cardiomyocytes	KEGG	ko04261
Thyroid hormone signaling pathway	KEGG	hsa04919
Inflammatory mediator regulation of TRP channels	KEGG	hsa04750
Inflammatory mediator regulation of TRP channels	KEGG	ko04750
Platelet activation	KEGG	hsa04611
Oxytocin signaling pathway	KEGG	hsa04921
Oxytocin signaling pathway	KEGG	ko04921
cAMP signaling pathway	KEGG	hsa04024
cAMP signaling pathway	KEGG	ko04024
cAMP signaling	KEGG	hsa_M00695
cAMP signaling	KEGG	M00695
Glucagon signaling pathway	KEGG	hsa04922
Glucagon signaling pathway	KEGG	ko04922
Regulation of lipolysis in adipocytes	KEGG	hsa04923
Renin secretion	KEGG	hsa04924
Renin secretion	KEGG	ko04924
Neuronal System	REACTOME	R-HSA-112316
Transmission across Chemical Synapses	REACTOME	R-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	REACTOME	R-HSA-112314
Activation of NMDA receptor upon glutamate binding and postsynaptic events	REACTOME	R-HSA-442755
Post NMDA receptor activation events	REACTOME	R-HSA-438064
CREB phosphorylation through the activation of Adenylate Cyclase	REACTOME	R-HSA-442720
Organelle biogenesis and maintenance	REACTOME	R-HSA-1852241
Cilium Assembly	REACTOME	R-HSA-5617833
Anchoring of the basal body to the plasma membrane	REACTOME	R-HSA-5620912
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Rap1 signalling	REACTOME	R-HSA-392517
Innate Immune System	REACTOME	R-HSA-168249
DAP12 interactions	REACTOME	R-HSA-2172127
DAP12 signaling	REACTOME	R-HSA-2424491
DAG and IP3 signaling	REACTOME	R-HSA-1489509
CaM pathway	REACTOME	R-HSA-111997
Calmodulin induced events	REACTOME	R-HSA-111933
PKA-mediated phosphorylation of CREB	REACTOME	R-HSA-111931
PKA activation	REACTOME	R-HSA-163615
C-type lectin receptors (CLRs)	REACTOME	R-HSA-5621481
CD209 (DC-SIGN) signaling	REACTOME	R-HSA-5621575
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-3, 5 and GM-CSF signaling	REACTOME	R-HSA-512988
Hemostasis	REACTOME	R-HSA-109582
Factors involved in megakaryocyte development and platelet production	REACTOME	R-HSA-983231
Signal Transduction	REACTOME	R-HSA-162582
Signaling by EGFR	REACTOME	R-HSA-177929
EGFR interacts with phospholipase C-gamma	REACTOME	R-HSA-212718
Signalling by NGF	REACTOME	R-HSA-166520
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
PLC-gamma1 signalling	REACTOME	R-HSA-167021
Signaling by PDGF	REACTOME	R-HSA-186797
Downstream signal transduction	REACTOME	R-HSA-186763
Signaling by VEGF	REACTOME	R-HSA-194138
VEGFA-VEGFR2 Pathway	REACTOME	R-HSA-4420097
MAPK family signaling cascades	REACTOME	R-HSA-5683057
MAPK6/MAPK4 signaling	REACTOME	R-HSA-5687128
Signaling by GPCR	REACTOME	R-HSA-372790
Opioid Signalling	REACTOME	R-HSA-111885
G-protein mediated events	REACTOME	R-HSA-112040
PLC beta mediated events	REACTOME	R-HSA-112043
Ca-dependent events	REACTOME	R-HSA-111996
DARPP-32 events	REACTOME	R-HSA-180024
Signaling by Hedgehog	REACTOME	R-HSA-5358351
Hedgehog 'off' state	REACTOME	R-HSA-5610787
GLI3 is processed to GLI3R by the proteasome	REACTOME	R-HSA-5610785
Degradation of GLI2 by the proteasome	REACTOME	R-HSA-5610783
Degradation of GLI1 by the proteasome	REACTOME	R-HSA-5610780
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
Mitotic G2-G2/M phases	REACTOME	R-HSA-453274
G2/M Transition	REACTOME	R-HSA-69275
Regulation of PLK1 Activity at G2/M Transition	REACTOME	R-HSA-2565942
Centrosome maturation	REACTOME	R-HSA-380287
Recruitment of mitotic centrosome proteins and complexes	REACTOME	R-HSA-380270
Loss of proteins required for interphase microtubule organization from the centrosome	REACTOME	R-HSA-380284
Loss of Nlp from mitotic centrosomes	REACTOME	R-HSA-380259
Muscle contraction	REACTOME	R-HSA-397014
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
Aquaporin-mediated transport	REACTOME	R-HSA-445717
Vasopressin regulates renal water homeostasis via Aquaporins	REACTOME	R-HSA-432040
Metabolism	REACTOME	R-HSA-1430728
Metabolism of carbohydrates	REACTOME	R-HSA-71387
Glucose metabolism	REACTOME	R-HSA-70326
Gluconeogenesis	REACTOME	R-HSA-70263
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Lipid digestion, mobilization, and transport	REACTOME	R-HSA-73923
Lipoprotein metabolism	REACTOME	R-HSA-174824
HDL-mediated lipid transport	REACTOME	R-HSA-194223
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis	REACTOME	R-HSA-163560
Integration of energy metabolism	REACTOME	R-HSA-163685
Regulation of insulin secretion	REACTOME	R-HSA-422356
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	REACTOME	R-HSA-381676
Glucagon signaling in metabolic regulation	REACTOME	R-HSA-163359
PKA activation in glucagon signalling	REACTOME	R-HSA-164378
PKA-mediated phosphorylation of key metabolic factors	REACTOME	R-HSA-163358
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
Aldosterone synthesis and secretion	KEGG	hsa04925
Aldosterone synthesis and secretion	KEGG	ko04925
Longevity regulating pathway	KEGG	hsa04211
Cardiac conduction	REACTOME	R-HSA-5576891
Ion homeostasis	REACTOME	R-HSA-5578775
Longevity regulating pathway - multiple species	KEGG	ko04213
Longevity regulating pathway - multiple species	KEGG	hsa04213
AURKA Activation by TPX2	REACTOME	R-HSA-8854518
Endocrine resistance	KEGG	ko01522
Endocrine resistance	KEGG	hsa01522
RET signaling	REACTOME	R-HSA-8853659
Apelin signaling pathway	KEGG	hsa04371

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association
PA26008	CACNA1B	Gene	Pathway	associated
PA30616	MAPK1	Gene	Pathway	associated
PA33639	PPP1R1B	Gene	Pathway	associated
PA59	ARRB1	Gene	Pathway	associated
PA60	ARRB2	Gene	Pathway	associated
PA83	CACNA1C	Gene	Pathway	associated
PA84	CACNA1D	Gene	Pathway	associated
PA85	CACNA1S	Gene	Pathway	associated

References

Pubmed ID	Year	Title	Citations
37871652	2024	Gene Rearrangement and Expression of PRKACA and PRKACB Govern Morphobiology of Pancreatobiliary Oncocytic Neoplasms.	1
38445884	2024	The PKA-CREB1 axis regulates coronavirus proliferation by viral helicase nsp13 association.	0
38552737	2024	Protein kinase A is a functional component of focal adhesions.	1
37871652	2024	Gene Rearrangement and Expression of PRKACA and PRKACB Govern Morphobiology of Pancreatobiliary Oncocytic Neoplasms.	1
38445884	2024	The PKA-CREB1 axis regulates coronavirus proliferation by viral helicase nsp13 association.	0
38552737	2024	Protein kinase A is a functional component of focal adhesions.	1
37146970	2023	PKA mediates modality-specific modulation of the mechanically gated ion channel PIEZO2.	1
37146970	2023	PKA mediates modality-specific modulation of the mechanically gated ion channel PIEZO2.	1
35167623	2022	DNAJB1-PRKACA in HEK293T cells induces LINC00473 overexpression that depends on PKA signaling.	5
36152045	2022	Investigation of -PRKACA/-PRKACB fusion genes in oncocytic tumors of the pancreatobiliary and other systems.	1
36446603	2022	Defective synaptic plasticity in a model of Coffin-Lowry syndrome is rescued by simultaneously targeting PKA and MAPK pathways.	0
35167623	2022	DNAJB1-PRKACA in HEK293T cells induces LINC00473 overexpression that depends on PKA signaling.	5
36152045	2022	Investigation of -PRKACA/-PRKACB fusion genes in oncocytic tumors of the pancreatobiliary and other systems.	1
36446603	2022	Defective synaptic plasticity in a model of Coffin-Lowry syndrome is rescued by simultaneously targeting PKA and MAPK pathways.	0
33572403	2021	Protein Kinase A-Mediated Septin7 Phosphorylation Disrupts Septin Filaments and Ciliogenesis.	2

Citation

Dessen P

PRKACA (protein kinase cAMP-activated catalytic subunit alpha)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41846/prkaca

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