PRKAR2A (protein kinase cAMP-dependent type II regulatory subunit alpha)

2007-02-01  

Identity

HGNC
LOCATION
3p21.31
LOCUSID
ALIAS
PKR2,PRKAR2
FUSION GENES

Other Information

Locus ID:

NCBI: 5576
MIM: 176910
HGNC: 9391
Ensembl: ENSG00000114302

Variants:

dbSNP: 5576
ClinVar: 5576
TCGA: ENSG00000114302
COSMIC: PRKAR2A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000114302ENST00000265563P13861
ENSG00000114302ENST00000265563A0A024R2W3
ENSG00000114302ENST00000296446P13861
ENSG00000114302ENST00000296446A0A0S2Z472
ENSG00000114302ENST00000419216C9J830
ENSG00000114302ENST00000437821H7C1L0
ENSG00000114302ENST00000438535H7C4A9
ENSG00000114302ENST00000454963P13861
ENSG00000114302ENST00000454963A0A024R2W3
ENSG00000114302ENST00000457914H7C330

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Insulin signaling pathwayKEGGko04910
Insulin signaling pathwayKEGGhsa04910
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
DAP12 interactionsREACTOMER-HSA-2172127
DAP12 signalingREACTOMER-HSA-2424491
DAG and IP3 signalingREACTOMER-HSA-1489509
CaM pathwayREACTOMER-HSA-111997
Calmodulin induced eventsREACTOMER-HSA-111933
PKA-mediated phosphorylation of CREBREACTOMER-HSA-111931
PKA activationREACTOMER-HSA-163615
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
Signal TransductionREACTOMER-HSA-162582
Signaling by EGFRREACTOMER-HSA-177929
EGFR interacts with phospholipase C-gammaREACTOMER-HSA-212718
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
PLC-gamma1 signallingREACTOMER-HSA-167021
Signaling by PDGFREACTOMER-HSA-186797
Downstream signal transductionREACTOMER-HSA-186763
Signaling by GPCRREACTOMER-HSA-372790
Opioid SignallingREACTOMER-HSA-111885
G-protein mediated eventsREACTOMER-HSA-112040
PLC beta mediated eventsREACTOMER-HSA-112043
Ca-dependent eventsREACTOMER-HSA-111996
DARPP-32 eventsREACTOMER-HSA-180024
Signaling by HedgehogREACTOMER-HSA-5358351
Hedgehog 'off' stateREACTOMER-HSA-5610787
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Aquaporin-mediated transportREACTOMER-HSA-445717
Vasopressin regulates renal water homeostasis via AquaporinsREACTOMER-HSA-432040
MetabolismREACTOMER-HSA-1430728
Integration of energy metabolismREACTOMER-HSA-163685
Regulation of insulin secretionREACTOMER-HSA-422356
Glucagon-like Peptide-1 (GLP1) regulates insulin secretionREACTOMER-HSA-381676
Glucagon signaling in metabolic regulationREACTOMER-HSA-163359
PKA activation in glucagon signallingREACTOMER-HSA-164378

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
170819892006Molecular basis of AKAP specificity for PKA regulatory subunits.118
178846352007Isoform-specific PKA dynamics revealed by dye-triggered aggregation and DAKAP1alpha-mediated localization in living cells.27
167234982006Efficient trafficking of MDR1/P-glycoprotein to apical canalicular plasma membranes in HepG2 cells requires PKA-RIIalpha anchoring and glucosylceramide.26
203791462010Biological pathway-based genome-wide association analysis identified the vasoactive intestinal peptide (VIP) pathway important for obesity.22
193072162009Bacillus anthracis edema toxin suppresses human macrophage phagocytosis and cytoskeletal remodeling via the protein kinase A and exchange protein activated by cyclic AMP pathways.17
163941272005Tumor reversion: protein kinase A isozyme switching.15
193675812010Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population.13
207080172010Structure of the AML1-ETO NHR3-PKA(RIIα) complex and its contribution to AML1-ETO activity.11
233622812013Protein kinase A modulates transforming growth factor-β signaling through a direct interaction with Smad4 protein.11
239420522013Human heart failure is accompanied by altered protein kinase A subunit expression and post-translational state.11

Citation

Dessen P

PRKAR2A (protein kinase cAMP-dependent type II regulatory subunit alpha)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45624/prkar2a