Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PRKCA (protein kinase C alpha)

Identity

Alias (NCBI)AAG6
PKC-alpha
PKCA
PKCI+/-
PKCalpha
PRKACA
HGNC (Hugo) PRKCA
HGNC Alias symbPKC??
HGNC Previous namePKCA
HGNC Previous nameprotein kinase C, alpha
LocusID (NCBI) 5578
Atlas_Id 41851
Location 17q24.2  [Link to chromosome band 17q24]
Location_base_pair Starts at 66302613 and ends at 66810743 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ALG5 (13q13.3) / PRKCA (17q24.2)G6PD (Xq28) / PRKCA (17q24.2)IGF2BP3 (7p15.3) / PRKCA (17q24.2)
INO80 (15q15.1) / PRKCA (17q24.2)KIRREL (1q23.1) / PRKCA (17q24.2)PITPNC1 (17q24.2) / PRKCA (17q24.2)
PRKCA (17q24.2) / ATP2A2 (12q24.11)PRKCA (17q24.2) / CDH8 (16q21)PRKCA (17q24.2) / CRYBA1 (17q11.2)
PRKCA (17q24.2) / GALNT13 (2q23.3)PRKCA (17q24.2) / IGF2BP1 (17q21.32)PRKCA (17q24.2) / LYZ (12q15)
PRKCA (17q24.2) / PAFAH1B1 (17p13.3)PRKCA (17q24.2) / PBX1 (1q23.3)PRKCA (17q24.2) / PITPNC1 (17q24.2)
PRKCA (17q24.2) / SDK1 (7p22.2)PRKCA (17q24.2) / SLC45A3 (1q32.1)PRKCA (17q24.2) / ST6GALNAC2 (17q25.1)
SLC44A1 (9q31.1) / PRKCA (17q24.2)TANC2 (17q23.2) / PRKCA (17q24.2)UNK (17q25.1) / PRKCA (17q24.2)
INO80 15q15.1 / PRKCA 17q24.2PRKCA 17q24.2 / CDH8 16q21PRKCA 17q24.2 / CRYBA1 17q11.2
PRKCA 17q24.2 / IGF2BP1 17q21.32PRKCA 17q24.2 / PITPNC1 17q24.2PRKCA 17q24.2 / SDK1 7p22.2
PRKCA 17q24.2 / ST6GALNAC2 17q25.1TANC2 17q23.2 / PRKCA 17q24.2UNK 17q25.1 / PRKCA 17q24.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 12 ]
  t(7;17)(p15;q24) IGF2BP3/PRKCA
t(7;17)(p22;q24) PRKCA/SDK1
t(9;17)(q31;q24) SLC44A1/PRKCA
t(15;17)(q15;q24) INO80/PRKCA
t(16;17)(q21;q24) PRKCA/CDH8
t(17;17)(q11;q24) PRKCA/CRYBA1
t(17;17)(q21;q24) PRKCA/IGF2BP1
t(17;17)(q23;q24) TANC2/PRKCA
PITPNC1/PRKCA (17q24)
PRKCA/PITPNC1 (17q24)
t(17;17)(q24;q25) PRKCA/ST6GALNAC2
t(17;17)(q24;q25) UNK/PRKCA

External links

Nomenclature
HGNC (Hugo)PRKCA   9393
Cards
Entrez_Gene (NCBI)PRKCA  5578  protein kinase C alpha
AliasesAAG6; PKC-alpha; PKCA; PKCI+/-; 
PKCalpha; PRKACA
GeneCards (Weizmann)PRKCA
Ensembl hg19 (Hinxton)ENSG00000154229 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000154229 [Gene_View]  ENSG00000154229 [Sequence]  chr17:66302613-66810743 [Contig_View]  PRKCA [Vega]
ICGC DataPortalENSG00000154229
TCGA cBioPortalPRKCA
AceView (NCBI)PRKCA
Genatlas (Paris)PRKCA
WikiGenes5578
SOURCE (Princeton)PRKCA
Genetics Home Reference (NIH)PRKCA
Genomic and cartography
GoldenPath hg38 (UCSC)PRKCA  -     chr17:66302613-66810743 +  17q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRKCA  -     17q24.2   [Description]    (hg19-Feb_2009)
GoldenPathPRKCA - 17q24.2 [CytoView hg19]  PRKCA - 17q24.2 [CytoView hg38]
ImmunoBaseENSG00000154229
genome Data Viewer NCBIPRKCA [Mapview hg19]  
OMIM176960   
Gene and transcription
Genbank (Entrez)AA017296 AB209475 AB451258 AB451383 AF035594
RefSeq transcript (Entrez)NM_002737
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PRKCA
Alternative Splicing GalleryENSG00000154229
Gene ExpressionPRKCA [ NCBI-GEO ]   PRKCA [ EBI - ARRAY_EXPRESS ]   PRKCA [ SEEK ]   PRKCA [ MEM ]
Gene Expression Viewer (FireBrowse)PRKCA [ Firebrowse - Broad ]
GenevisibleExpression of PRKCA in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5578
GTEX Portal (Tissue expression)PRKCA
Human Protein AtlasENSG00000154229-PRKCA [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP17252   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP17252  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP17252
Splice isoforms : SwissVarP17252
PhosPhoSitePlusP17252
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    C2 (PS50004)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domains : Interpro (EBI)AGC-kinase_C    C2_dom    C2_domain_sf    cPKC_alpha    DAG/PE-bd    Kinase-like_dom_sf    PE/DAG-bd    Pkinase_C    Prot_kinase_dom    Protein_kinase_ATP_BS    Protein_kinase_C_a/b/g    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)C1_1 (PF00130)    C2 (PF00168)    Pkinase (PF00069)    Pkinase_C (PF00433)   
Domain families : Pfam (NCBI)pfam00130    pfam00168    pfam00069    pfam00433   
Domain families : Smart (EMBL)C1 (SM00109)  C2 (SM00239)  S_TK_X (SM00133)  S_TKc (SM00220)  
Conserved Domain (NCBI)PRKCA
DMDM Disease mutations5578
Blocks (Seattle)PRKCA
PDB (RSDB)2ELI    3IW4    4DNL    4RA4   
PDB Europe2ELI    3IW4    4DNL    4RA4   
PDB (PDBSum)2ELI    3IW4    4DNL    4RA4   
PDB (IMB)2ELI    3IW4    4DNL    4RA4   
Structural Biology KnowledgeBase2ELI    3IW4    4DNL    4RA4   
SCOP (Structural Classification of Proteins)2ELI    3IW4    4DNL    4RA4   
CATH (Classification of proteins structures)2ELI    3IW4    4DNL    4RA4   
SuperfamilyP17252
Human Protein Atlas [tissue]ENSG00000154229-PRKCA [tissue]
Peptide AtlasP17252
HPRD01498
IPIIPI00385449   IPI00887297   IPI01012363   IPI00748556   IPI00977298   
Protein Interaction databases
DIP (DOE-UCLA)P17252
IntAct (EBI)P17252
FunCoupENSG00000154229
BioGRIDPRKCA
STRING (EMBL)PRKCA
ZODIACPRKCA
Ontologies - Pathways
QuickGOP17252
Ontology : AmiGOangiogenesis  positive regulation of endothelial cell proliferation  desmosome assembly  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein kinase C activity  calcium-dependent protein kinase C activity  integrin binding  protein binding  ATP binding  nucleoplasm  cytoplasm  mitochondrion  endoplasmic reticulum  cytosol  cytosol  plasma membrane  plasma membrane  protein phosphorylation  mitotic nuclear envelope disassembly  cell adhesion  axon guidance  zinc ion binding  positive regulation of endothelial cell migration  positive regulation of cardiac muscle hypertrophy  peptidyl-serine phosphorylation  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  enzyme binding  platelet activation  positive regulation of cell migration  positive regulation of lipopolysaccharide-mediated signaling pathway  mitochondrial membrane  negative regulation of glial cell apoptotic process  histone kinase activity (H3-T6 specific)  histone H3-T6 phosphorylation  intracellular signal transduction  alphav-beta3 integrin-PKCalpha complex  ERBB2 signaling pathway  regulation of mRNA stability  positive regulation of blood vessel endothelial cell migration  positive regulation of macrophage differentiation  positive regulation of angiogenesis  positive regulation of bone resorption  positive regulation of cell adhesion  positive regulation of mitotic cell cycle  perinuclear region of cytoplasm  regulation of insulin secretion  extracellular exosome  positive regulation of ERK1 and ERK2 cascade  response to interleukin-1  regulation of platelet aggregation  apoptotic signaling pathway  positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway  positive regulation of dense core granule biogenesis  
Ontology : EGO-EBIangiogenesis  positive regulation of endothelial cell proliferation  desmosome assembly  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein kinase C activity  calcium-dependent protein kinase C activity  integrin binding  protein binding  ATP binding  nucleoplasm  cytoplasm  mitochondrion  endoplasmic reticulum  cytosol  cytosol  plasma membrane  plasma membrane  protein phosphorylation  mitotic nuclear envelope disassembly  cell adhesion  axon guidance  zinc ion binding  positive regulation of endothelial cell migration  positive regulation of cardiac muscle hypertrophy  peptidyl-serine phosphorylation  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  enzyme binding  platelet activation  positive regulation of cell migration  positive regulation of lipopolysaccharide-mediated signaling pathway  mitochondrial membrane  negative regulation of glial cell apoptotic process  histone kinase activity (H3-T6 specific)  histone H3-T6 phosphorylation  intracellular signal transduction  alphav-beta3 integrin-PKCalpha complex  ERBB2 signaling pathway  regulation of mRNA stability  positive regulation of blood vessel endothelial cell migration  positive regulation of macrophage differentiation  positive regulation of angiogenesis  positive regulation of bone resorption  positive regulation of cell adhesion  positive regulation of mitotic cell cycle  perinuclear region of cytoplasm  regulation of insulin secretion  extracellular exosome  positive regulation of ERK1 and ERK2 cascade  response to interleukin-1  regulation of platelet aggregation  apoptotic signaling pathway  positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway  positive regulation of dense core granule biogenesis  
Pathways : KEGGMAPK signaling pathway    ErbB signaling pathway    Ras signaling pathway    Rap1 signaling pathway    Calcium signaling pathway    HIF-1 signaling pathway    Phosphatidylinositol signaling system    mTOR signaling pathway    PI3K-Akt signaling pathway    Adrenergic signaling in cardiomyocytes    Vascular smooth muscle contraction    Wnt signaling pathway    VEGF signaling pathway    Focal adhesion    Tight junction    Gap junction    Natural killer cell mediated cytotoxicity    Fc epsilon RI signaling pathway    Fc gamma R-mediated phagocytosis    Leukocyte transendothelial migration    Circadian entrainment    Long-term potentiation    Retrograde endocannabinoid signaling    Glutamatergic synapse    Cholinergic synapse    Serotonergic synapse    GABAergic synapse    Dopaminergic synapse    Long-term depression    Insulin secretion    GnRH signaling pathway    Melanogenesis    Thyroid hormone synthesis    Thyroid hormone signaling pathway    Aldosterone-regulated sodium reabsorption    Endocrine and other factor-regulated calcium reabsorption    Salivary secretion    Gastric acid secretion    Pancreatic secretion    Amphetamine addiction    Morphine addiction    Vibrio cholerae infection    Pathogenic Escherichia coli infection    African trypanosomiasis    Amoebiasis    Hepatitis B    Influenza A    Pathways in cancer    Proteoglycans in cancer    MicroRNAs in cancer    Glioma    Non-small cell lung cancer   
NDEx NetworkPRKCA
Atlas of Cancer Signalling NetworkPRKCA
Wikipedia pathwaysPRKCA
Orthology - Evolution
OrthoDB5578
GeneTree (enSembl)ENSG00000154229
Phylogenetic Trees/Animal Genes : TreeFamPRKCA
HOGENOMP17252
Homologs : HomoloGenePRKCA
Homology/Alignments : Family Browser (UCSC)PRKCA
Gene fusions - Rearrangements
Fusion : MitelmanINO80/PRKCA [15q15.1/17q24.2]  
Fusion : MitelmanPRKCA/CDH8 [17q24.2/16q21]  
Fusion : MitelmanPRKCA/CRYBA1 [17q24.2/17q11.2]  
Fusion : MitelmanPRKCA/IGF2BP1 [17q24.2/17q21.32]  
Fusion : MitelmanPRKCA/PITPNC1 [17q24.2/17q24.2]  
Fusion : MitelmanPRKCA/SDK1 [17q24.2/7p22.2]  
Fusion : MitelmanPRKCA/ST6GALNAC2 [17q24.2/17q25.1]  
Fusion : MitelmanSLC44A1/PRKCA [9q31.1/17q24.2]  
Fusion : MitelmanTANC2/PRKCA [17q23.2/17q24.2]  
Fusion : MitelmanUNK/PRKCA [17q25.1/17q24.2]  
Fusion PortalINO80 15q15.1 PRKCA 17q24.2 BRCA
Fusion PortalPRKCA 17q24.2 CDH8 16q21 BRCA
Fusion PortalPRKCA 17q24.2 CRYBA1 17q11.2 BRCA
Fusion PortalPRKCA 17q24.2 IGF2BP1 17q21.32 BRCA
Fusion PortalPRKCA 17q24.2 PITPNC1 17q24.2 LUAD SKCM
Fusion PortalPRKCA 17q24.2 SDK1 7p22.2 LUSC
Fusion PortalPRKCA 17q24.2 ST6GALNAC2 17q25.1 BRCA
Fusion PortalTANC2 17q23.2 PRKCA 17q24.2 LUSC
Fusion PortalUNK 17q25.1 PRKCA 17q24.2 KIRC
Fusion : QuiverPRKCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRKCA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRKCA
dbVarPRKCA
ClinVarPRKCA
MonarchPRKCA
1000_GenomesPRKCA 
Exome Variant ServerPRKCA
GNOMAD BrowserENSG00000154229
Varsome BrowserPRKCA
Genetic variants : HAPMAP5578
Genomic Variants (DGV)PRKCA [DGVbeta]
DECIPHERPRKCA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRKCA 
Mutations
ICGC Data PortalPRKCA 
TCGA Data PortalPRKCA 
Broad Tumor PortalPRKCA
OASIS PortalPRKCA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRKCA  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPRKCA
Mutations and Diseases : HGMDPRKCA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRKCA
DgiDB (Drug Gene Interaction Database)PRKCA
DoCM (Curated mutations)PRKCA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRKCA (select a term)
intoGenPRKCA
Cancer3DPRKCA(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176960   
Orphanet
DisGeNETPRKCA
MedgenPRKCA
Genetic Testing Registry PRKCA
NextProtP17252 [Medical]
TSGene5578
GENETestsPRKCA
Target ValidationPRKCA
Huge Navigator PRKCA [HugePedia]
snp3D : Map Gene to Disease5578
BioCentury BCIQPRKCA
ClinGenPRKCA
Clinical trials, drugs, therapy
Protein Interactions : CTD5578
Pharm GKB GenePA33759
Pharm GKB PathwaysPA152530845   PA162356267   PA2024   PA2032   
Clinical trialPRKCA
Miscellaneous
canSAR (ICR)PRKCA (select the gene name)
HarmonizomePRKCA
DataMed IndexPRKCA
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRKCA
EVEXPRKCA
GoPubMedPRKCA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Sep 14 14:28:15 CEST 2020
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