Identity
HGNC
LOCATION
2p21
LOCUSID
ALIAS
PKCE,nPKC-epsilon
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5581
MIM: 176975
HGNC: 9401
Ensembl: ENSG00000171132
Variants:
dbSNP: 5581
ClinVar: 5581
TCGA: ENSG00000171132
COSMIC: PRKCE
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000171132 | ENST00000306156 | Q02156 |
| ENSG00000171132 | ENST00000306156 | L7RTI5 |
| ENSG00000171132 | ENST00000394874 | E9PBI2 |
| ENSG00000171132 | ENST00000421201 | C9JR22 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA166122986 | radiotherapy | Chemical | ClinicalAnnotation | associated | PD | 25054431 | |
| PA33392 | PLCG1 | Gene | Pathway | associated | 20124951 | ||
| PA33393 | PLCG2 | Gene | Pathway | associated | 20124951 | ||
| PA34183 | RAF1 | Gene | Pathway | associated | 20124951 | ||
| PA39 | ADRB2 | Gene | Pathway | associated | |||
| PA62 | ATP1A1 | Gene | Pathway | associated | 23788015 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38656553 | 2024 | The binding of PKCε and MEG2 to STAT3 regulates IL-6-mediated microglial hyperalgesia during inflammatory pain. | 0 |
| 38656553 | 2024 | The binding of PKCε and MEG2 to STAT3 regulates IL-6-mediated microglial hyperalgesia during inflammatory pain. | 0 |
| 36400183 | 2023 | Protein kinase C epsilon promotes de novo lipogenesis and tumor growth in prostate cancer cells by regulating the phosphorylation and nuclear translocation of pyruvate kinase isoform M2. | 1 |
| 36782184 | 2023 | Elucidating the role of missense SNP of protein kinase C epsilon in HCV-induced hepatocellular carcinoma. | 1 |
| 37336366 | 2023 | Apolipoprotein E ε4 triggers neurotoxicity via cholesterol accumulation, acetylcholine dyshomeostasis, and PKCε mislocalization in cholinergic neuronal cells. | 3 |
| 37501577 | 2023 | Effects of PKCε knockdown on mitochondrial membrane potential of human glioma cells in vitro and growth of U251 cell-derived tumors in vivo. | 0 |
| 37833790 | 2023 | Cross talk of tumor protein D52 (TPD52) with KLF9, PKCε, and MicroRNA 223 in ovarian cancer. | 1 |
| 36400183 | 2023 | Protein kinase C epsilon promotes de novo lipogenesis and tumor growth in prostate cancer cells by regulating the phosphorylation and nuclear translocation of pyruvate kinase isoform M2. | 1 |
| 36782184 | 2023 | Elucidating the role of missense SNP of protein kinase C epsilon in HCV-induced hepatocellular carcinoma. | 1 |
| 37336366 | 2023 | Apolipoprotein E ε4 triggers neurotoxicity via cholesterol accumulation, acetylcholine dyshomeostasis, and PKCε mislocalization in cholinergic neuronal cells. | 3 |
| 37501577 | 2023 | Effects of PKCε knockdown on mitochondrial membrane potential of human glioma cells in vitro and growth of U251 cell-derived tumors in vivo. | 0 |
| 37833790 | 2023 | Cross talk of tumor protein D52 (TPD52) with KLF9, PKCε, and MicroRNA 223 in ovarian cancer. | 1 |
| 34108094 | 2022 | Genome-wide DNA methylation profiling in nonalcoholic fatty liver reveals predictive aberrant methylation in PRKCE and SEC14L3 promoters. | 5 |
| 34108094 | 2022 | Genome-wide DNA methylation profiling in nonalcoholic fatty liver reveals predictive aberrant methylation in PRKCE and SEC14L3 promoters. | 5 |
| 31648598 | 2021 | PKCε regulates Rho GTPases and actin cytoskeleton reorganization in non-small cell lung cancer cells. | 8 |
Citation
Dessen P
PRKCE (protein kinase C epsilon)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/41855/prkce
