PRKCQ (protein kinase C theta)

2003-11-01 Affiliation

Identity

HGNC

PRKCQ

LOCATION

10p15.1

LOCUSID

5588

ALIAS

PRKCT,nPKC-theta

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5588
MIM: 600448
HGNC: 9410
Ensembl: ENSG00000065675

Variants:

dbSNP: 5588
ClinVar: 5588
TCGA: ENSG00000065675
COSMIC: PRKCQ

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000065675	ENST00000263125	Q04759
ENSG00000065675	ENST00000397176	Q04759
ENSG00000065675	ENST00000539722	Q04759
ENSG00000065675	ENST00000610727	A0A087X0I9

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Autophagy - animal	KEGG	ko04140
T cell receptor signaling pathway	KEGG	ko04660
Adipocytokine signaling pathway	KEGG	ko04920
Autophagy - animal	KEGG	hsa04140
T cell receptor signaling pathway	KEGG	hsa04660
Adipocytokine signaling pathway	KEGG	hsa04920
Vascular smooth muscle contraction	KEGG	hsa04270
Vascular smooth muscle contraction	KEGG	ko04270
Measles	KEGG	ko05162
Measles	KEGG	hsa05162
NF-kappa B signaling pathway	KEGG	hsa04064
NF-kappa B signaling pathway	KEGG	ko04064
Inflammatory mediator regulation of TRP channels	KEGG	hsa04750
Inflammatory mediator regulation of TRP channels	KEGG	ko04750
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
TCR signaling	REACTOME	R-HSA-202403
Downstream TCR signaling	REACTOME	R-HSA-202424
Innate Immune System	REACTOME	R-HSA-168249
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
FCERI mediated NF-kB activation	REACTOME	R-HSA-2871837
Hemostasis	REACTOME	R-HSA-109582
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
Effects of PIP2 hydrolysis	REACTOME	R-HSA-114508
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (z) signalling events	REACTOME	R-HSA-418597
G alpha (q) signalling events	REACTOME	R-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907
Visual phototransduction	REACTOME	R-HSA-2187338
The phototransduction cascade	REACTOME	R-HSA-2514856
Inactivation, recovery and regulation of the phototransduction cascade	REACTOME	R-HSA-2514859
Programmed Cell Death	REACTOME	R-HSA-5357801
Apoptosis	REACTOME	R-HSA-109581
Apoptotic execution phase	REACTOME	R-HSA-75153
Apoptotic cleavage of cellular proteins	REACTOME	R-HSA-111465
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
Netrin-1 signaling	REACTOME	R-HSA-373752
Insulin resistance	KEGG	hsa04931
Th1 and Th2 cell differentiation	KEGG	ko04658
Th1 and Th2 cell differentiation	KEGG	hsa04658
Th17 cell differentiation	KEGG	ko04659
Th17 cell differentiation	KEGG	hsa04659

PharmGKB

Entity ID	Name	Type	Evidence	Association	PMIDs
PA33392	PLCG1	Gene	Pathway	associated	20124951
PA33393	PLCG2	Gene	Pathway	associated	20124951
PA34183	RAF1	Gene	Pathway	associated	20124951
PA39	ADRB2	Gene	Pathway	associated

References

Pubmed ID	Year	Title	Citations
19073967	2008	Shared and distinct genetic variants in type 1 diabetes and celiac disease.	249
15358536	2004	PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta.	210
18794853	2008	Common variants at CD40 and other loci confer risk of rheumatoid arthritis.	199
20339032	2010	Protein kinase C-theta mediates negative feedback on regulatory T cell function.	124
24979806	2014	Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans.	96
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
19240061	2009	Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.	75
16385451	2006	A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.	69
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
15064353	2004	Diacylglycerol-dependent binding recruits PKCtheta and RasGRP1 C1 domains to specific subcellular localizations in living T lymphocytes.	58

Citation

Dessen P

PRKCQ (protein kinase C theta)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41861/prkcq