PRKD2 (protein kinase D2)

2004-06-01 Affiliation

Identity

HGNC

PRKD2

LOCATION

19q13.32

LOCUSID

25865

ALIAS

HSPC187,PKD2,nPKC-D2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 25865
MIM: 607074
HGNC: 17293
Ensembl: ENSG00000105287

Variants:

dbSNP: 25865
ClinVar: 25865
TCGA: ENSG00000105287
COSMIC: PRKD2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000105287	ENST00000291281	Q9BZL6
ENSG00000105287	ENST00000433867	Q9BZL6
ENSG00000105287	ENST00000593363	M0R346
ENSG00000105287	ENST00000595132	M0QZ82
ENSG00000105287	ENST00000595515	Q9BZL6
ENSG00000105287	ENST00000597390	M0R2Z8
ENSG00000105287	ENST00000597641	M0QXC6
ENSG00000105287	ENST00000598633	M0R012
ENSG00000105287	ENST00000600194	Q9BZL6
ENSG00000105287	ENST00000601605	M0QZC2
ENSG00000105287	ENST00000601806	Q9BZL6

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Rap1 signaling pathway	KEGG	hsa04015
Rap1 signaling pathway	KEGG	ko04015
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Sphingolipid metabolism	REACTOME	R-HSA-428157
Sphingolipid de novo biosynthesis	REACTOME	R-HSA-1660661
Aldosterone synthesis and secretion	KEGG	hsa04925
Aldosterone synthesis and secretion	KEGG	ko04925

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
18758461	2008	A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia.	143
14743217	2004	Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network.	94
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
22734003	2012	Rab5c promotes AMAP1-PRKD2 complex formation to enhance β1 integrin recycling in EGF-induced cancer invasion.	44
20732914	2010	Protein kinase D2 is a crucial regulator of tumour cell-endothelial cell communication in gastrointestinal tumours.	42
21173164	2011	Ligand-stimulated downregulation of the alpha interferon receptor: role of protein kinase D2.	40
17570131	2008	PKD, PKD2, and p38 MAPK mediate Hsp27 serine-82 phosphorylation induced by neurotensin in pancreatic cancer PANC-1 cells.	39
15604256	2004	Protein kinase D2 mediates activation of nuclear factor kappaB by Bcr-Abl in Bcr-Abl+ human myeloid leukemia cells.	35
16928771	2007	Protein kinase D2 mediates lysophosphatidic acid-induced interleukin 8 production in nontransformed human colonic epithelial cells through NF-kappaB.	33
15975900	2005	Role of the regulatory domain of protein kinase D2 in phorbol ester binding, catalytic activity, and nucleocytoplasmic shuttling.	23

Citation

Dessen P

PRKD2 (protein kinase D2)

Atlas Genet Cytogenet Oncol Haematol. 2004-06-01

Online version: http://atlasgeneticsoncology.org/gene/42916/prkd2