PRKRA (protein activator of interferon induced protein kinase EIF2AK2)

2013-01-01  

Identity

HGNC
LOCATION
2q31.2
LOCUSID
ALIAS
DYT16,HSD14,PACT,RAX
FUSION GENES

Other Information

Locus ID:

NCBI: 8575
MIM: 603424
HGNC: 9438
Ensembl: ENSG00000180228

Variants:

dbSNP: 8575
ClinVar: 8575
TCGA: ENSG00000180228
COSMIC: PRKRA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000180228ENST00000325748O75569
ENSG00000180228ENST00000424699G5E9Q4
ENSG00000180228ENST00000432031O75569
ENSG00000180228ENST00000448279F8WEG8
ENSG00000180228ENST00000457633C9JMM3
ENSG00000180228ENST00000487082O75569

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Gene Silencing by RNAREACTOMER-HSA-211000
MicroRNA (miRNA) biogenesisREACTOMER-HSA-203927
Small interfering RNA (siRNA) biogenesisREACTOMER-HSA-426486

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
164249072006The role of PACT in the RNA silencing pathway.241
174523272007Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA.104
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
245229212014Middle east respiratory syndrome coronavirus 4a protein is a double-stranded RNA-binding protein that suppresses PACT-induced activation of RIG-I and MDA5 in the innate antiviral response.85
238703152013Mutual antagonism between the Ebola virus VP35 protein and the RIG-I activator PACT determines infection outcome.82
215018292011The double-stranded RNA-binding protein PACT functions as a cellular activator of RIG-I to facilitate innate antiviral response.75
236616842013Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing.73
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
189361602009TRBP control of PACT-induced phosphorylation of protein kinase R is reversed by stress.55
123683482002Inhibition of PACT-mediated activation of PKR by the herpes simplex virus type 1 Us11 protein.52

Citation

Dessen P

PRKRA (protein activator of interferon induced protein kinase EIF2AK2)

Atlas Genet Cytogenet Oncol Haematol. 2013-01-01

Online version: http://atlasgeneticsoncology.org/gene/53143/prkra