PRL (prolactin)

2003-08-01  

Identity

HGNC
PRL
LOCATION
6p22.3
LOCUSID
5617
ALIAS
GHA1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5617
MIM: 176760
HGNC: 9445
Ensembl: ENSG00000172179

Variants:

dbSNP: 5617
ClinVar: 5617
TCGA: ENSG00000172179
COSMIC: PRL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172179ENST00000306482P01236
ENSG00000172179ENST00000306482Q5THQ0
ENSG00000172179ENST00000615510A6XMH3
ENSG00000172179ENST00000617911Q5I0G2
ENSG00000172179ENST00000651245A0A494C0Z0
ENSG00000172179ENST00000651757A0A494C1P2

Expression (GTEx)

0
10000
20000
30000
40000
50000
60000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Neuroactive ligand-receptor interactionKEGGko04080
Jak-STAT signaling pathwayKEGGko04630
Cytokine-cytokine receptor interactionKEGGhsa04060
Neuroactive ligand-receptor interactionKEGGhsa04080
Jak-STAT signaling pathwayKEGGhsa04630
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Prolactin signaling pathwayKEGGhsa04917
Prolactin signaling pathwayKEGGko04917
Metabolism of proteinsREACTOMER-HSA-392499
Amyloid fiber formationREACTOMER-HSA-977225
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Growth hormone receptor signalingREACTOMER-HSA-982772
Prolactin receptor signalingREACTOMER-HSA-1170546

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
pituitary gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
172895762007A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy.183
236193652013MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy.120
235300352013Stiff collagen matrices increase tumorigenic prolactin signaling in breast cancer cells.63
119234742002PRL activates the cyclin D1 promoter via the Jak2/Stat pathway.56
182071342008Genes controlling affiliative behavior as candidate genes for autism.56
182071342008Genes controlling affiliative behavior as candidate genes for autism.56
207340642010A large-scale candidate gene association study of age at menarche and age at natural menopause.38
175076242007Evaluation of genetic variations in the androgen and estrogen metabolic pathways as risk factors for sporadic and familial prostate cancer.37
198513402009Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population.37
201244772010Prolactin inhibits BCL6 expression in breast cancer through a Stat5a-dependent mechanism.36

Citation

Dessen P

PRL (prolactin)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41868/prl