PRLHR (prolactin releasing hormone receptor)

2007-02-01  

Identity

HGNC
LOCATION
10q26.11
LOCUSID
ALIAS
GPR10,GR3,PrRPR

Other Information

Locus ID:

NCBI: 2834
MIM: 600895
HGNC: 4464
Ensembl: ENSG00000119973

Variants:

dbSNP: 2834
ClinVar: 2834
TCGA: ENSG00000119973
COSMIC: PRLHR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000119973ENST00000239032P49683
ENSG00000119973ENST00000636925P49683

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
232841712013Loss of the repressor REST in uterine fibroids promotes aberrant G protein-coupled receptor 10 expression and activates mammalian target of rapamycin pathway.20
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
263028492015Polymorphisms of PRLHR and HSPA12A and risk of gastric and colorectal cancer in the Chinese Han population.7
146911962004Association between physical activity and blood pressure is modified by variants in the G-protein coupled receptor 10.6
124173112002NRSF/REST confers transcriptional repression of the GPR10 gene via a putative NRSE/RE-1 located in the 5' promoter region.4
127167692003Association of polymorphisms in GPR10, the gene encoding the prolactin-releasing peptide receptor with blood pressure, but not obesity, in a U.K. Caucasian population.4
127167692003Association of polymorphisms in GPR10, the gene encoding the prolactin-releasing peptide receptor with blood pressure, but not obesity, in a U.K. Caucasian population.4
157525832005Characterization of a naturally-occurring polymorphism in the UHR-1 gene encoding the putative rat prolactin-releasing peptide receptor.4
227782592012Ligand-mimicking receptor variant discloses binding and activation mode of prolactin-releasing peptide.4

Citation

Dessen P

PRLHR (prolactin releasing hormone receptor)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46075/prlhr