PRM1 (protamine 1)

2016-10-01  

Identity

HGNC
PRM1
LOCATION
16p13.13
LOCUSID
5619
ALIAS
CT94.1,P1

Other Information

Locus ID:

NCBI: 5619
MIM: 182880
HGNC: 9447
Ensembl: ENSG00000175646

Variants:

dbSNP: 5619
ClinVar: 5619
TCGA: ENSG00000175646
COSMIC: PRM1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000175646ENST00000312511P04553
ENSG00000175646ENST00000312511Q3MN80

Expression (GTEx)

0
5000
10000
15000
20000
25000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203786152010Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent.40
170115552006Sperm protamine 1/protamine 2 ratios are related to in vitro fertilization pregnancy rates and predictive of fertilization ability.24
184781562008Characterization of nucleohistone and nucleoprotamine components in the mature human sperm nucleus.17
125691752003Single nucleotide polymorphisms in the protamine-1 and -2 genes of fertile and infertile human male populations.16
125691752003Single nucleotide polymorphisms in the protamine-1 and -2 genes of fertile and infertile human male populations.16
174941042007Mutations in the protamine 1 gene associated with male infertility.16
169898272006Identification of novel polymorphisms in the nuclear protein genes and their relationship with human sperm protamine deficiency and severe male infertility.14
169898272006Identification of novel polymorphisms in the nuclear protein genes and their relationship with human sperm protamine deficiency and severe male infertility.14
196025092009Mutations in the protamine locus: association with spermatogenic failure?13
196025092009Mutations in the protamine locus: association with spermatogenic failure?13

Citation

Dessen P

PRM1 (protamine 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56123/prm1