PRMT1 (protein arginine methyltransferase 1)

2007-12-01  

Identity

HGNC
LOCATION
19q13.33
LOCUSID
ALIAS
ANM1,HCP1,HRMT1L2,IR1B4
FUSION GENES

Other Information

Locus ID:

NCBI: 3276
MIM: 602950
HGNC: 5187
Ensembl: ENSG00000126457

Variants:

dbSNP: 3276
ClinVar: 3276
TCGA: ENSG00000126457
COSMIC: PRMT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000126457ENST00000391851Q99873
ENSG00000126457ENST00000454376Q99873
ENSG00000126457ENST00000524771H0YDE4
ENSG00000126457ENST00000526224E9PNR9
ENSG00000126457ENST00000527382E9PQ98
ENSG00000126457ENST00000528623E9PMZ2
ENSG00000126457ENST00000529284E9PNR9
ENSG00000126457ENST00000529836E9PMW9
ENSG00000126457ENST00000532489E9PKG1
ENSG00000126457ENST00000534280E9PIE2
ENSG00000126457ENST00000534465E9PIX6
ENSG00000126457ENST00000610806Q99873

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
FoxO signaling pathwayKEGGhsa04068
Glucagon signaling pathwayKEGGhsa04922
Glucagon signaling pathwayKEGGko04922
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
RMTs methylate histone argininesREACTOMER-HSA-3214858
TP53 Regulates Transcription of Cell Cycle GenesREACTOMER-HSA-6791312
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle ArrestREACTOMER-HSA-6804114

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
178911362007Protein arginine-methyltransferase-dependent oncogenesis.102
204738592011Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers.97
186575042008Regulation of estrogen rapid signaling through arginine methylation by PRMT1.95
211726652010TDRD3 is an effector molecule for arginine-methylated histone marks.88
157413142005Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control.77
219652982012Arginine methylation by PRMT1 regulates nuclear-cytoplasmic localization and toxicity of FUS/TLS harbouring ALS-linked mutations.76
183164802008Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity.68
178485682007Alternative splicing yields protein arginine methyltransferase 1 isoforms with distinct activity, substrate specificity, and subcellular localization.62
242966202014Protein arginine methylation of non-histone proteins and its role in diseases.55
234197482013Loss of the major Type I arginine methyltransferase PRMT1 causes substrate scavenging by other PRMTs.54

Citation

Dessen P

PRMT1 (protein arginine methyltransferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49941/prmt1