PRMT2 (protein arginine methyltransferase 2)

2008-01-01  

Identity

HGNC
LOCATION
21q22.3
LOCUSID
ALIAS
HRMT1L1
FUSION GENES

Other Information

Locus ID:

NCBI: 3275
MIM: 601961
HGNC: 5186
Ensembl: ENSG00000160310

Variants:

dbSNP: 3275
ClinVar: 3275
TCGA: ENSG00000160310
COSMIC: PRMT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160310ENST00000291705P55345
ENSG00000160310ENST00000334494P55345
ENSG00000160310ENST00000355680P55345
ENSG00000160310ENST00000355680A0A0S2Z3N3
ENSG00000160310ENST00000397628A8MXR3
ENSG00000160310ENST00000397637P55345
ENSG00000160310ENST00000397637A0A0S2Z3N3
ENSG00000160310ENST00000397638P55345
ENSG00000160310ENST00000397638A0A0S2Z3N3
ENSG00000160310ENST00000440086P55345
ENSG00000160310ENST00000451211P55345
ENSG00000160310ENST00000455177H7C2H9
ENSG00000160310ENST00000458387P55345
ENSG00000160310ENST00000621201A0A087WYX1

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
120399522002Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha.44
194059102009Kinetic analysis of human protein arginine N-methyltransferase 2: formation of monomethyl- and asymmetric dimethyl-arginine residues on histone H4.38
191611602009An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1).30
220933642012Identification and characterization of novel spliced variants of PRMT2 in breast carcinoma.24
166484812006Protein methyltransferase 2 inhibits NF-kappaB function and promotes apoptosis.22
175875662007PRMT2, a member of the protein arginine methyltransferase family, is a coactivator of the androgen receptor.22
249111192014PRMT2 and RORγ expression are associated with breast cancer survival outcomes.16
218510902011A protein arginine N-methyltransferase 1 (PRMT1) and 2 heteromeric interaction increases PRMT1 enzymatic activity.9
242926722014Nuclear loss of protein arginine N-methyltransferase 2 in breast carcinoma is associated with tumor grade and overexpression of cyclin D1 protein.9
218200402011Identification and expression analysis of a novel transcript of the human PRMT2 gene resulted from alternative polyadenylation in breast cancer.8

Citation

Dessen P

PRMT2 (protein arginine methyltransferase 2)

Atlas Genet Cytogenet Oncol Haematol. 2008-01-01

Online version: http://atlasgeneticsoncology.org/gene/49971/prmt2