PRMT5 (protein arginine methyltransferase 5)

2007-02-01  

Identity

HGNC
LOCATION
14q11.2
LOCUSID
ALIAS
HRMT1L5,HSL7,IBP72,JBP1,SKB1,SKB1Hs
FUSION GENES

Other Information

Locus ID:

NCBI: 10419
MIM: 604045
HGNC: 10894
Ensembl: ENSG00000100462

Variants:

dbSNP: 10419
ClinVar: 10419
TCGA: ENSG00000100462
COSMIC: PRMT5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100462ENST00000216350O14744
ENSG00000100462ENST00000324366O14744
ENSG00000100462ENST00000397440O14744
ENSG00000100462ENST00000397441O14744
ENSG00000100462ENST00000421938C9JSX3
ENSG00000100462ENST00000454731H7BZ44
ENSG00000100462ENST00000553502H0YJ77
ENSG00000100462ENST00000553550G3V2L6
ENSG00000100462ENST00000553787G3V507
ENSG00000100462ENST00000553897O14744
ENSG00000100462ENST00000553915G3V3A3
ENSG00000100462ENST00000554867G3V580
ENSG00000100462ENST00000554910G3V5L5
ENSG00000100462ENST00000555454H0YJD3
ENSG00000100462ENST00000555530H0YJX6
ENSG00000100462ENST00000556043G3V5T6
ENSG00000100462ENST00000556616G3V2X6
ENSG00000100462ENST00000557415G3V2F5
ENSG00000100462ENST00000557443H0YJY6
ENSG00000100462ENST00000627278G3V507

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
RNA transportKEGGko03013
RNA transportKEGGhsa03013
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Metabolism of non-coding RNAREACTOMER-HSA-194441
snRNP AssemblyREACTOMER-HSA-191859
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
RMTs methylate histone argininesREACTOMER-HSA-3214858
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through MethylationREACTOMER-HSA-6804760

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
154859292004Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes.236
192344652009PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing.185
145599962003mSin3A/histone deacetylase 2- and PRMT5-containing Brg1 complex is involved in transcriptional repression of the Myc target gene cad.115
211598182010Prmt5 is essential for early mouse development and acts in the cytoplasm to maintain ES cell pluripotency.115
176272752007Low levels of miR-92b/96 induce PRMT5 translation and H3R8/H4R3 methylation in mantle cell lymphoma.109
186949592008Protein arginine methyltransferase 5 suppresses the transcription of the RB family of tumor suppressors in leukemia and lymphoma cells.103
222314002012Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance.101
209519432010Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase.96
213166062011JAK2V617F-mediated phosphorylation of PRMT5 downregulates its methyltransferase activity and promotes myeloproliferation.93
183470602008The LIM protein AJUBA recruits protein arginine methyltransferase 5 to mediate SNAIL-dependent transcriptional repression.91

Citation

Dessen P

PRMT5 (protein arginine methyltransferase 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45521/prmt5