PRMT6 (protein arginine methyltransferase 6)

2009-06-01  

Identity

HGNC
LOCATION
1p13.3
LOCUSID
ALIAS
HRMT1L6

Other Information

Locus ID:

NCBI: 55170
MIM: 608274
HGNC: 18241
Ensembl: ENSG00000198890

Variants:

dbSNP: 55170
ClinVar: 55170
TCGA: ENSG00000198890
COSMIC: PRMT6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198890ENST00000370078Q96LA8
ENSG00000198890ENST00000650338A0A3B3ITK4

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
RMTs methylate histone argininesREACTOMER-HSA-3214858

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
178987142007Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive.173
180791822007PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation.111
204738592011Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers.97
155968082005Methylation of Tat by PRMT6 regulates human immunodeficiency virus type 1 gene expression.80
180774602008Arginine methylation of the histone H3 tail impedes effector binding.77
197543112009Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03).53
172675052007Arginine methylation of the human immunodeficiency virus type 1 Tat protein by PRMT6 negatively affects Tat Interactions with both cyclin T1 and the Tat transactivation region.52
239801572013H3R42me2a is a histone modification with positive transcriptional effects.36
171764732006PRMT6 diminishes HIV-1 Rev binding to and export of viral RNA.29
195092932009Thrombospondin-1 is a transcriptional repression target of PRMT6.25

Citation

Dessen P

PRMT6 (protein arginine methyltransferase 6)

Atlas Genet Cytogenet Oncol Haematol. 2009-06-01

Online version: http://atlasgeneticsoncology.org/gene/50961/prmt6