PROC (protein C, inactivator of coagulation factors Va and VIIIa)

2007-02-01 Affiliation

Identity

HGNC

PROC

LOCATION

2q14.3

LOCUSID

5624

ALIAS

APC,PC,PROC1,THPH3,THPH4

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5624
MIM: 612283
HGNC: 9451
Ensembl: ENSG00000115718

Variants:

dbSNP: 5624
ClinVar: 5624
TCGA: ENSG00000115718
COSMIC: PROC

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000115718	ENST00000234071	P04070
ENSG00000115718	ENST00000402125	H7BYX9
ENSG00000115718	ENST00000409048	E7END6
ENSG00000115718	ENST00000419985	F2Z2A0
ENSG00000115718	ENST00000427769	E7EU72
ENSG00000115718	ENST00000429925	E7EVH6
ENSG00000115718	ENST00000431364	F2Z2A0
ENSG00000115718	ENST00000442644	E7ENR9

Expression (GTEx)

100

150

200

250

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Complement and coagulation cascades	KEGG	ko04610
Complement and coagulation cascades	KEGG	hsa04610
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Gamma carboxylation, hypusine formation and arylsulfatase activation	REACTOME	R-HSA-163841
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	REACTOME	R-HSA-159854
Gamma-carboxylation of protein precursors	REACTOME	R-HSA-159740
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus	REACTOME	R-HSA-159763
Removal of aminoterminal propeptides from gamma-carboxylated proteins	REACTOME	R-HSA-159782
Hemostasis	REACTOME	R-HSA-109582
Formation of Fibrin Clot (Clotting Cascade)	REACTOME	R-HSA-140877
Intrinsic Pathway of Fibrin Clot Formation	REACTOME	R-HSA-140837
Common Pathway of Fibrin Clot Formation	REACTOME	R-HSA-140875
Cell surface interactions at the vascular wall	REACTOME	R-HSA-202733

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA165290929	ethinyl estradiol / norelgestromin	Chemical	LabelAnnotation	associated
PA165816542	CYP2C9*1	Haplotype	LabelAnnotation	associated
PA165816543	CYP2C9*2	Haplotype	LabelAnnotation	associated
PA165816544	CYP2C9*3	Haplotype	LabelAnnotation	associated
PA166155091	rs9923231	Variant	LabelAnnotation	associated
PA166179849	avatrombopag	Chemical	LabelAnnotation	associated
PA166182748	lusutrombopag	Chemical	LabelAnnotation	associated
PA166190221	estradiol / progesterone	Chemical	LabelAnnotation	associated
PA28660	GGCX	Gene	Pathway	associated
PA450921	phenprocoumon	Chemical	ClinicalAnnotation	associated	PK	PD
PA451906	warfarin	Chemical	LabelAnnotation, VariantAnnotation	ambiguous		PD	19794411

References

Pubmed ID	Year	Title	Citations
12052963	2002	Activation of endothelial cell protease activated receptor 1 by the protein C pathway.	247
12563316	2003	Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective.	169
15710622	2005	Activated protein C mediates novel lung endothelial barrier enhancement: role of sphingosine 1-phosphate receptor transactivation.	153
17982464	2007	Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis.	133
17048007	2007	Association of warfarin dose with genes involved in its action and metabolism.	100
15178554	2004	Thrombomodulin-protein C-EPCR system: integrated to regulate coagulation and inflammation.	92
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
15769747	2005	Protease-activated receptor-1 signaling by activated protein C in cytokine-perturbed endothelial cells is distinct from thrombin signaling.	73
15516929	2004	Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C.	72
15665002	2005	PAR1 cleavage and signaling in response to activated protein C and thrombin.	63

Citation

Dessen P

PROC (protein C, inactivator of coagulation factors Va and VIIIa)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46329/proc