Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5624
MIM: 612283
HGNC: 9451
Ensembl: ENSG00000115718
Variants:
dbSNP: 5624
ClinVar: 5624
TCGA: ENSG00000115718
COSMIC: PROC
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA165290929 | ethinyl estradiol / norelgestromin | Chemical | LabelAnnotation | associated | |||
| PA165816542 | CYP2C9*1 | Haplotype | LabelAnnotation | associated | |||
| PA165816543 | CYP2C9*2 | Haplotype | LabelAnnotation | associated | |||
| PA165816544 | CYP2C9*3 | Haplotype | LabelAnnotation | associated | |||
| PA166155091 | rs9923231 | Variant | LabelAnnotation | associated | |||
| PA166179849 | avatrombopag | Chemical | LabelAnnotation | associated | |||
| PA166182748 | lusutrombopag | Chemical | LabelAnnotation | associated | |||
| PA166190221 | estradiol / progesterone | Chemical | LabelAnnotation | associated | |||
| PA28660 | GGCX | Gene | Pathway | associated | |||
| PA450921 | phenprocoumon | Chemical | ClinicalAnnotation | associated | PK | PD | |
| PA451906 | warfarin | Chemical | LabelAnnotation, VariantAnnotation | ambiguous | PD | 19794411 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37950050 | 2024 | Analysis of PROC mutations and clinical features in 22 unrelated families with inherited protein C deficiency. | 0 |
| 37950050 | 2024 | Analysis of PROC mutations and clinical features in 22 unrelated families with inherited protein C deficiency. | 0 |
| 36588134 | 2023 | APC ameliorates idiopathic membranous nephropathy by affecting podocyte apoptosis through the ERK1/2/YB-1/PLA2R1 axis. | 1 |
| 37657561 | 2023 | Design and characterization of novel activated protein C variants for the proteolysis of cytotoxic extracellular histone H3. | 2 |
| 37660436 | 2023 | Activated protein C, protein S, and tissue factor pathway inhibitor cooperate to inhibit thrombin activation. | 1 |
| 38015884 | 2023 | Computational analysis of the functional and structural impact of the most deleterious missense mutations in the human Protein C. | 0 |
| 38135361 | 2023 | Activated Protein C Prevents Neuronal Apoptosis via Protease Activated Receptors 1 and 3. | 0 |
| 36588134 | 2023 | APC ameliorates idiopathic membranous nephropathy by affecting podocyte apoptosis through the ERK1/2/YB-1/PLA2R1 axis. | 1 |
| 37657561 | 2023 | Design and characterization of novel activated protein C variants for the proteolysis of cytotoxic extracellular histone H3. | 2 |
| 37660436 | 2023 | Activated protein C, protein S, and tissue factor pathway inhibitor cooperate to inhibit thrombin activation. | 1 |
| 38015884 | 2023 | Computational analysis of the functional and structural impact of the most deleterious missense mutations in the human Protein C. | 0 |
| 38135361 | 2023 | Activated Protein C Prevents Neuronal Apoptosis via Protease Activated Receptors 1 and 3. | 0 |
| 34978431 | 2022 | How Thrombomodulin Enables W215A/E217A Thrombin to Cleave Protein C but Not Fibrinogen. | 0 |
| 35008942 | 2022 | Activated Protein C Protects against Murine Contact Dermatitis by Suppressing Protease-Activated Receptor 2. | 4 |
| 35031071 | 2022 | The prognostic utility of protein C as a biomarker for adult sepsis: a systematic review and meta-analysis. | 5 |
Citation
Dessen P
PROC (protein C, inactivator of coagulation factors Va and VIIIa)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46329/proc
