PROS1 (protein S)

2007-02-01 Affiliation

Identity

HGNC

PROS1

LOCATION

3q11.1

LOCUSID

5627

ALIAS

PROS,PS21,PS22,PS23,PS24,PS25,PSA,THPH5,THPH6

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5627
MIM: 176880
HGNC: 9456
Ensembl: ENSG00000184500

Variants:

dbSNP: 5627
ClinVar: 5627
TCGA: ENSG00000184500
COSMIC: PROS1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000184500	ENST00000348974	P07225
ENSG00000184500	ENST00000348974	A0A0S2Z4K3
ENSG00000184500	ENST00000394236	P07225
ENSG00000184500	ENST00000394236	A0A0S2Z4K3
ENSG00000184500	ENST00000407433	G5E9F8
ENSG00000184500	ENST00000472684	C9K0R0
ENSG00000184500	ENST00000647936	A0A3B3IRK9
ENSG00000184500	ENST00000648853	A0A3B3ISJ1
ENSG00000184500	ENST00000649103	A0A3B3ITZ7
ENSG00000184500	ENST00000649585	A0A3B3IUA6
ENSG00000184500	ENST00000650591	A0A0S2Z4L3

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Complement and coagulation cascades	KEGG	ko04610
Complement and coagulation cascades	KEGG	hsa04610
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Gamma carboxylation, hypusine formation and arylsulfatase activation	REACTOME	R-HSA-163841
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	REACTOME	R-HSA-159854
Gamma-carboxylation of protein precursors	REACTOME	R-HSA-159740
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus	REACTOME	R-HSA-159763
Removal of aminoterminal propeptides from gamma-carboxylated proteins	REACTOME	R-HSA-159782
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Complement cascade	REACTOME	R-HSA-166658
Regulation of Complement cascade	REACTOME	R-HSA-977606
Hemostasis	REACTOME	R-HSA-109582
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
Response to elevated platelet cytosolic Ca2+	REACTOME	R-HSA-76005
Platelet degranulation	REACTOME	R-HSA-114608
Formation of Fibrin Clot (Clotting Cascade)	REACTOME	R-HSA-140877
Common Pathway of Fibrin Clot Formation	REACTOME	R-HSA-140875
Cell surface interactions at the vascular wall	REACTOME	R-HSA-202733

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association
PA165290929	ethinyl estradiol / norelgestromin	Chemical	LabelAnnotation	associated
PA165816542	CYP2C9*1	Haplotype	LabelAnnotation	associated
PA165816543	CYP2C9*2	Haplotype	LabelAnnotation	associated
PA165816544	CYP2C9*3	Haplotype	LabelAnnotation	associated
PA166155091	rs9923231	Variant	LabelAnnotation	associated
PA166179849	avatrombopag	Chemical	LabelAnnotation	associated
PA166182748	lusutrombopag	Chemical	LabelAnnotation	associated
PA166190221	estradiol / progesterone	Chemical	LabelAnnotation	associated
PA28660	GGCX	Gene	Pathway	associated
PA451906	warfarin	Chemical	LabelAnnotation	associated

References

Pubmed ID	Year	Title	Citations
12447359	2003	Serum-derived protein S binds to phosphatidylserine and stimulates the phagocytosis of apoptotic cells.	106
16488980	2006	Protein S stimulates inhibition of the tissue factor pathway by tissue factor pathway inhibitor.	83
23850380	2013	T cell-derived protein S engages TAM receptor signaling in dendritic cells to control the magnitude of the immune response.	58
20348395	2010	Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor.	48
12907438	2004	Coagulation, inflammation, and apoptosis: different roles for protein S and the protein S-C4b binding protein complex.	44
20673868	2010	A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).	36
18250462	2008	Auto-oxidation and oligomerization of protein S on the apoptotic cell surface is required for Mer tyrosine kinase-mediated phagocytosis of apoptotic cells.	34
17849042	2007	Molecular basis of protein S deficiency.	31
20452482	2010	Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes.	26
12193728	2002	Vitamin K-dependent protein S localizing complement regulator C4b-binding protein to the surface of apoptotic cells.	25

Citation

Dessen P

PROS1 (protein S)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46212/pros1