PROZ (protein Z, vitamin K dependent plasma glycoprotein)

2009-08-01 Affiliation

Identity

HGNC

PROZ

LOCATION

13q34

LOCUSID

8858

ALIAS

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 8858
MIM: 176895
HGNC: 9460
Ensembl: ENSG00000126231

Variants:

dbSNP: 8858
ClinVar: 8858
TCGA: ENSG00000126231
COSMIC: PROZ

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000126231	ENST00000342783	P22891
ENSG00000126231	ENST00000375547	P22891

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Gamma carboxylation, hypusine formation and arylsulfatase activation	REACTOME	R-HSA-163841
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	REACTOME	R-HSA-159854
Gamma-carboxylation of protein precursors	REACTOME	R-HSA-159740
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus	REACTOME	R-HSA-159763
Removal of aminoterminal propeptides from gamma-carboxylated proteins	REACTOME	R-HSA-159782

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA28660	GGCX	Gene	Pathway	associated

References

Pubmed ID	Year	Title	Citations
17048007	2007	Association of warfarin dose with genes involved in its action and metabolism.	100
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
22689435	2012	Methylome analysis and integrative profiling of human HCCs identify novel protumorigenic factors.	60
17701666	2007	Preeclampsia is associated with low concentrations of protein Z.	15
20427285	2010	Basis for the specificity and activation of the serpin protein Z-dependent proteinase inhibitor (ZPI) as an inhibitor of membrane-associated factor Xa.	15
14652653	2003	Low protein Z plasma levels are independently associated with acute coronary syndromes.	14
19729601	2009	Candidate gene polymorphisms for ischemic stroke.	14
12297123	2002	Protein Z influences the prothrombotic phenotype in Factor V Leiden patients.	13
12970515	2003	Protein Z in ischemic stroke and its etiologic subtypes.	12
15748239	2005	Protein Z, protein S levels are lower in patients with thrombophilia and subsequent pregnancy complications.	12

Citation

Dessen P

PROZ (protein Z, vitamin K dependent plasma glycoprotein)

Atlas Genet Cytogenet Oncol Haematol. 2009-08-01

Online version: http://atlasgeneticsoncology.org/gene/51035/proz