PRPF19 (pre-mRNA processing factor 19)

2004-04-01  

Identity

HGNC
PRPF19
LOCATION
11q12.2
LOCUSID
27339
ALIAS
NMP200,PRP19,PSO4,SNEV,UBOX4,hPSO4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 27339
MIM: 608330
HGNC: 17896
Ensembl: ENSG00000110107

Variants:

dbSNP: 27339
ClinVar: 27339
TCGA: ENSG00000110107
COSMIC: PRPF19

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110107ENST00000227524Q9UMS4
ENSG00000110107ENST00000535326H0YGZ5
ENSG00000110107ENST00000540473H0YGF3
ENSG00000110107ENST00000541371F5GY56
ENSG00000110107ENST00000546152F5H2I0

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Spliceosome, Prp19/CDC5L complexKEGGhsa_M00353
Spliceosome, 35S U5-snRNPKEGGhsa_M00355
Spliceosome, Prp19/CDC5L complexKEGGM00353
Spliceosome, 35S U5-snRNPKEGGM00355
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
DNA RepairREACTOMER-HSA-73894
Nucleotide Excision RepairREACTOMER-HSA-5696398
Transcription-Coupled Nucleotide Excision Repair (TC-NER)REACTOMER-HSA-6781827
Formation of TC-NER Pre-Incision ComplexREACTOMER-HSA-6781823
Dual incision in TC-NERREACTOMER-HSA-6782135
Gap-filling DNA repair synthesis and ligation in TC-NERREACTOMER-HSA-6782210

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
151756532004A subset of human 35S U5 proteins, including Prp19, function prior to catalytic step 1 of splicing.84
243328082014PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.83
215367362011The RNA polymerase II C-terminal domain promotes splicing activation through recruitment of a U2AF65-Prp19 complex.67
162237182005The Pso4 mRNA splicing and DNA repair complex interacts with WRN for processing of DNA interstrand cross-links.61
201768112010Molecular architecture of the human Prp19/CDC5L complex.51
129603892003Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase.47
182638762008Human Pso4 is a metnase (SETMAR)-binding partner that regulates metnase function in DNA repair.37
172763912007The Prp19/Pso4 core complex undergoes ubiquitylation and structural alterations in response to DNA damage.28
163888002006SNEV overexpression extends the life span of human endothelial cells.24
232200102013Ubiquitin C-terminal Hydrolase 37, a novel predictor for hepatocellular carcinoma recurrence, promotes cell migration and invasion via interacting and deubiquitinating PRP19.24

Citation

Dessen P

PRPF19 (pre-mRNA processing factor 19)

Atlas Genet Cytogenet Oncol Haematol. 2004-04-01

Online version: http://atlasgeneticsoncology.org/gene/41876/prpf19