PRPS2 (phosphoribosyl pyrophosphate synthetase 2)

2015-08-01  

Identity

HGNC
LOCATION
Xp22.2
LOCUSID
ALIAS
PRSII
FUSION GENES

Other Information

Locus ID:

NCBI: 5634
MIM: 311860
HGNC: 9465
Ensembl: ENSG00000101911

Variants:

dbSNP: 5634
ClinVar: 5634
TCGA: ENSG00000101911
COSMIC: PRPS2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101911ENST00000380663A6NMS2
ENSG00000101911ENST00000380668P11908
ENSG00000101911ENST00000398491P11908
ENSG00000101911ENST00000398491A0A140VK41
ENSG00000101911ENST00000461630H7C540
ENSG00000101911ENST00000489404D3YTJ7

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Pentose phosphate pathwayKEGGko00030
Purine metabolismKEGGko00230
Pentose phosphate pathwayKEGGhsa00030
Purine metabolismKEGGhsa00230
Metabolic pathwaysKEGGhsa01100
PRPP biosynthesis, ribose 5P => PRPPKEGGhsa_M00005
PRPP biosynthesis, ribose 5P => PRPPKEGGM00005
Biosynthesis of amino acidsKEGGhsa01230
Biosynthesis of amino acidsKEGGko01230
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
5-Phosphoribose 1-diphosphate biosynthesisREACTOMER-HSA-73843

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
186771082008Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells.88
251494752015Meta-analysis of GWAS on two Chinese populations followed by replication identifies novel genetic variants on the X chromosome associated with systemic lupus erythematosus.9
260048652015PRPS2 Expression Correlates with Sertoli-Cell Only Syndrome and Inhibits the Apoptosis of TM4 Sertoli Cells.5
309089122019Targeted Quantitative Kinome Analysis Identifies PRPS2 as a Promoter for Colorectal Cancer Metastasis.4
184095172008[Increased activity of PRPP synthetase].1
258166082014Expression of phosphoribosyl pyrophosphate synthetase genes in U87 glioma cells with ERN1 knockdown: effect of hypoxia and endoplasmic reticulum stress.1

Citation

Dessen P

PRPS2 (phosphoribosyl pyrophosphate synthetase 2)

Atlas Genet Cytogenet Oncol Haematol. 2015-08-01

Online version: http://atlasgeneticsoncology.org/gene/55367/prps2