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PRSS23 (serine protease 23)

Identity

Alias_namesprotease, serine 23
Alias_symbol (synonym)SPUVE
SIG13
Other aliasZSIG13
HGNC (Hugo) PRSS23
LocusID (NCBI) 11098
Atlas_Id 52748
Location 11q14.2  [Link to chromosome band 11q14]
Location_base_pair Starts at 86800240 and ends at 86811231 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BTN3A2 (6p22.2) / PRSS23 (11q14.2)EIF3E (8q23.1) / PRSS23 (11q14.2)FKBP8 (19p13.11) / PRSS23 (11q14.2)
PAK1 (11q13.5) / PRSS23 (11q14.2)PRSS23 (11q14.2) / CANX (5q35.3)PRSS23 (11q14.2) / LRPPRC (2p21)
PRSS23 (11q14.2) / MGP (12p12.3)PRSS23 (11q14.2) / PRSS23 (11q14.2)PRSS23 (11q14.2) / SPRY4 (5q31.3)
RDH11 (14q24.1) / PRSS23 (11q14.2)UBE2I (16p13.3) / PRSS23 (11q14.2)PAK1 11q13.5 / PRSS23 11q14.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  PAK1/PRSS23 (11q14)

External links

Nomenclature
HGNC (Hugo)PRSS23   14370
Cards
Entrez_Gene (NCBI)PRSS23  11098  serine protease 23
AliasesSIG13; SPUVE; ZSIG13
GeneCards (Weizmann)PRSS23
Ensembl hg19 (Hinxton)ENSG00000150687 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000150687 [Gene_View]  ENSG00000150687 [Sequence]  chr11:86800240-86811231 [Contig_View]  PRSS23 [Vega]
ICGC DataPortalENSG00000150687
TCGA cBioPortalPRSS23
AceView (NCBI)PRSS23
Genatlas (Paris)PRSS23
WikiGenes11098
SOURCE (Princeton)PRSS23
Genetics Home Reference (NIH)PRSS23
Genomic and cartography
GoldenPath hg38 (UCSC)PRSS23  -     chr11:86800240-86811231 +  11q14.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRSS23  -     11q14.2   [Description]    (hg19-Feb_2009)
GoldenPathPRSS23 - 11q14.2 [CytoView hg19]  PRSS23 - 11q14.2 [CytoView hg38]
ImmunoBaseENSG00000150687
Mapping of homologs : NCBIPRSS23 [Mapview hg19]  PRSS23 [Mapview hg38]
OMIM618376   
Gene and transcription
Genbank (Entrez)AF015287 AF193611 AK075362 AK304054 AK304301
RefSeq transcript (Entrez)NM_001293178 NM_001293179 NM_001293180 NM_007173
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PRSS23
Cluster EST : UnigeneHs.729257 [ NCBI ]
CGAP (NCI)Hs.729257
Alternative Splicing GalleryENSG00000150687
Gene ExpressionPRSS23 [ NCBI-GEO ]   PRSS23 [ EBI - ARRAY_EXPRESS ]   PRSS23 [ SEEK ]   PRSS23 [ MEM ]
Gene Expression Viewer (FireBrowse)PRSS23 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11098
GTEX Portal (Tissue expression)PRSS23
Human Protein AtlasENSG00000150687-PRSS23 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95084   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95084  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95084
Splice isoforms : SwissVarO95084
PhosPhoSitePlusO95084
Domaine pattern : Prosite (Expaxy)TRYPSIN_HIS (PS00134)   
Domains : Interpro (EBI)Peptidase_S1_PA    Trypsin_dom    TRYPSIN_HIS   
Domain families : Pfam (Sanger)Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00089   
Conserved Domain (NCBI)PRSS23
DMDM Disease mutations11098
Blocks (Seattle)PRSS23
SuperfamilyO95084
Human Protein Atlas [tissue]ENSG00000150687-PRSS23 [tissue]
Peptide AtlasO95084
HPRD07149
IPIIPI00026941   IPI00910747   IPI00978336   IPI00980316   IPI00982212   
Protein Interaction databases
DIP (DOE-UCLA)O95084
IntAct (EBI)O95084
FunCoupENSG00000150687
BioGRIDPRSS23
STRING (EMBL)PRSS23
ZODIACPRSS23
Ontologies - Pathways
QuickGOO95084
Ontology : AmiGOserine-type endopeptidase activity  nucleus  endoplasmic reticulum lumen  proteolysis  post-translational protein modification  cellular protein metabolic process  extracellular exosome  
Ontology : EGO-EBIserine-type endopeptidase activity  nucleus  endoplasmic reticulum lumen  proteolysis  post-translational protein modification  cellular protein metabolic process  extracellular exosome  
NDEx NetworkPRSS23
Atlas of Cancer Signalling NetworkPRSS23
Wikipedia pathwaysPRSS23
Orthology - Evolution
OrthoDB11098
GeneTree (enSembl)ENSG00000150687
Phylogenetic Trees/Animal Genes : TreeFamPRSS23
HOGENOMO95084
Homologs : HomoloGenePRSS23
Homology/Alignments : Family Browser (UCSC)PRSS23
Gene fusions - Rearrangements
Fusion : MitelmanPAK1/PRSS23 [11q13.5/11q14.2]  [t(11;11)(q14;q14)]  
Fusion PortalPAK1 11q13.5 PRSS23 11q14.2 BRCA
Fusion : QuiverPRSS23
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRSS23 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRSS23
dbVarPRSS23
ClinVarPRSS23
1000_GenomesPRSS23 
Exome Variant ServerPRSS23
ExAC (Exome Aggregation Consortium)ENSG00000150687
GNOMAD BrowserENSG00000150687
Varsome BrowserPRSS23
Genetic variants : HAPMAP11098
Genomic Variants (DGV)PRSS23 [DGVbeta]
DECIPHERPRSS23 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRSS23 
Mutations
ICGC Data PortalPRSS23 
TCGA Data PortalPRSS23 
Broad Tumor PortalPRSS23
OASIS PortalPRSS23 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRSS23  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPRSS23
Mutations and Diseases : HGMDPRSS23
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRSS23
DgiDB (Drug Gene Interaction Database)PRSS23
DoCM (Curated mutations)PRSS23 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRSS23 (select a term)
intoGenPRSS23
Cancer3DPRSS23(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM618376   
Orphanet
DisGeNETPRSS23
MedgenPRSS23
Genetic Testing Registry PRSS23
NextProtO95084 [Medical]
TSGene11098
GENETestsPRSS23
Target ValidationPRSS23
Huge Navigator PRSS23 [HugePedia]
snp3D : Map Gene to Disease11098
BioCentury BCIQPRSS23
ClinGenPRSS23
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11098
Chemical/Pharm GKB GenePA134952846
Clinical trialPRSS23
Miscellaneous
canSAR (ICR)PRSS23 (select the gene name)
DataMed IndexPRSS23
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRSS23
EVEXPRSS23
GoPubMedPRSS23
iHOPPRSS23
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 18:02:51 CET 2019
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