PRSS3 (serine protease 3)

2007-02-01  

Identity

HGNC
LOCATION
9p13.3
LOCUSID
ALIAS
MTG,PRSS4,T9,TRY3,TRY4
FUSION GENES

Other Information

Locus ID:

NCBI: 5646
MIM: 613578
HGNC: 9486
Ensembl: ENSG00000010438

Variants:

dbSNP: 5646
ClinVar: 5646
TCGA: ENSG00000010438
COSMIC: PRSS3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000010438ENST00000342836P35030
ENSG00000010438ENST00000361005P35030
ENSG00000010438ENST00000379405P35030
ENSG00000010438ENST00000429677P35030
ENSG00000010438ENST00000457896B1AN99

Expression (GTEx)

0
500
1000
1500
2000

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Pancreatic secretionKEGGko04972
Pancreatic secretionKEGGhsa04972
Protein digestion and absorptionKEGGko04974
Protein digestion and absorptionKEGGhsa04974
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
DefensinsREACTOMER-HSA-1461973
Alpha-defensinsREACTOMER-HSA-1462054
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of water-soluble vitamins and cofactorsREACTOMER-HSA-196849
Cobalamin (Cbl, vitamin B12) transport and metabolismREACTOMER-HSA-196741
Antimicrobial peptidesREACTOMER-HSA-6803157
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
159877132006Carcinogen exposure and gene promoter hypermethylation in bladder cancer.55
176236522007Trypsin IV or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia.47
145079092003Human mesotrypsin is a unique digestive protease specialized for the degradation of trypsin inhibitors.43
118274882002Crystal structure reveals basis for the inhibitor resistance of human brain trypsin.27
183636392008Trypsinogen IV, serotonin transporter transcript levels and serotonin content are increased in small intestine of irritable bowel syndrome patients.27
200353772010Mesotrypsin promotes malignant growth of breast cancer cells through shedding of CD109.23
209478882010PRSS3 promotes tumour growth and metastasis of human pancreatic cancer.23
199201522010The amyloid precursor protein/protease nexin 2 Kunitz inhibitor domain is a highly specific substrate of mesotrypsin.20
199241342010Keratinocytes synthesize enteropeptidase and multiple forms of trypsinogen during terminal differentiation.15
164124312006Myelin basic protein, an autoantigen in multiple sclerosis, is selectively processed by human trypsin 4.13

Citation

Dessen P

PRSS3 (serine protease 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45981/prss3