PRUNE2 (prune homolog 2 with BCH domain)

2007-02-01  

Identity

HGNC
PRUNE2
LOCATION
9q21.2
LOCUSID
158471
ALIAS
BMCC1,BNIPXL,C9orf65,KIAA0367
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 158471
MIM: 610691
HGNC: 25209
Ensembl: ENSG00000106772

Variants:

dbSNP: 158471
ClinVar: 158471
TCGA: ENSG00000106772
COSMIC: PRUNE2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106772ENST00000223609A0A0C4DFM3
ENSG00000106772ENST00000376713X6R9J3
ENSG00000106772ENST00000376717Q5JUB8
ENSG00000106772ENST00000376718Q8WUY3
ENSG00000106772ENST00000424866Q5JUB9
ENSG00000106772ENST00000426088H7BZH9
ENSG00000106772ENST00000428286E9PDC2
ENSG00000106772ENST00000443509A0A088AWP5

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
173606602007Highly accurate two-gene classifier for differentiating gastrointestinal stromal tumors and leiomyosarcomas.69
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
260804352015PRUNE2 is a human prostate cancer suppressor regulated by the intronic long noncoding RNA PCA3.62
193191832009New genomic structure for prostate cancer specific gene PCA3 within BMCC1: implications for prostate cancer detection and progression.25
197606272010Differential expression of PCA3 and its overlapping PRUNE2 transcript in prostate cancer.18
253872652015Whole-exome sequencing studies of parathyroid carcinomas reveal novel PRUNE2 mutations, distinctive mutational spectra related to APOBEC-catalyzed DNA mutagenesis and mutational enrichment in kinases associated with cell migration and invasion.18
162882182006Increased expression of proapoptotic BMCC1, a novel gene with the BNIP2 and Cdc42GAP homology (BCH) domain, is associated with favorable prognosis in human neuroblastomas.17
184456822008BNIP2 extra long inhibits RhoA and cellular transformation by Lbc RhoGEF via its BCH domain.13
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.12
179615072007Cleavage of BNIP-2 and BNIP-XL by caspases.8

Citation

Dessen P

PRUNE2 (prune homolog 2 with BCH domain)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43690/prune2