PSAT1 (phosphoserine aminotransferase 1)

2008-03-01  

Identity

HGNC
PSAT1
LOCATION
9q21.2
LOCUSID
29968
ALIAS
EPIP,NLS2,PSA,PSAT,PSATD
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 29968
MIM: 610936
HGNC: 19129
Ensembl: ENSG00000135069

Variants:

dbSNP: 29968
ClinVar: 29968
TCGA: ENSG00000135069
COSMIC: PSAT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135069ENST00000347159Q9Y617
ENSG00000135069ENST00000347159A0A024R280
ENSG00000135069ENST00000376588Q9Y617
ENSG00000135069ENST00000376588A0A024R222

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycine, serine and threonine metabolismKEGGko00260
Vitamin B6 metabolismKEGGko00750
Glycine, serine and threonine metabolismKEGGhsa00260
Vitamin B6 metabolismKEGGhsa00750
Metabolic pathwaysKEGGhsa01100
Serine biosynthesis, glycerate-3P => serineKEGGhsa_M00020
Serine biosynthesis, glycerate-3P => serineKEGGM00020
Biosynthesis of amino acidsKEGGhsa01230
Biosynthesis of amino acidsKEGGko01230
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Amino acid synthesis and interconversion (transamination)REACTOMER-HSA-70614
Serine biosynthesisREACTOMER-HSA-977347

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
182215022008Overexpression of phosphoserine aminotransferase PSAT1 stimulates cell growth and increases chemoresistance of colon cancer cells.50
251428622015PSAT1 regulates cyclin D1 degradation and sustains proliferation of non-small cell lung cancer cells.22
223604202012Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.18
251524572014Neu-Laxova syndrome is a heterogeneous metabolic disorder caused by defects in enzymes of the L-serine biosynthesis pathway.18
292169292017PSAT1 is regulated by ATF4 and enhances cell proliferation via the GSK3β/β-catenin/cyclin D1 signaling pathway in ER-negative breast cancer.17
273726502016Overexpression of Phosphoserine Aminotransferase 1 (PSAT1) Predicts Poor Prognosis and Associates with Tumor Progression in Human Esophageal Squamous Cell Carcinoma.14
126335002003Characterization of human phosphoserine aminotransferase involved in the phosphorylated pathway of L-serine biosynthesis.13
264395042015Clinical Implication of Serine Metabolism-Associated Enzymes in Colon Cancer.11
209557402011A novel balanced chromosomal translocation found in subjects with schizophrenia and schizotypal personality disorder: altered l-serine level associated with disruption of PSAT1 gene expression.8
285228552017Phosphoserine aminotransferase 1 is associated to poor outcome on tamoxifen therapy in recurrent breast cancer.7

Citation

Dessen P

PSAT1 (phosphoserine aminotransferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-03-01

Online version: http://atlasgeneticsoncology.org/gene/50075/psat1