Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PSMB7 (proteasome 20S subunit beta 7)

Identity

Alias (NCBI)Z
HGNC (Hugo) PSMB7
HGNC Previous nameproteasome (prosome, macropain) subunit, beta type, 7
LocusID (NCBI) 5695
Atlas_Id 50405
Location 9q33.3  [Link to chromosome band 9q33]
Location_base_pair Starts at 124353465 and ends at 124415442 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ANAPC1 (2q13) / PSMB7 (9q33.3)DCTN4 (5q33.1) / PSMB7 (9q33.3)FUS (16p11.2) / PSMB7 (9q33.3)
KDM5C (Xp11.22) / PSMB7 (9q33.3)LONRF1 (8p23.1) / PSMB7 (9q33.3)NR6A1 (9q33.3) / PSMB7 (9q33.3)
PSMB7 (9q33.3) / EEF1D (8q24.3)PSMB7 (9q33.3) / MARCH1 (4q32.2)PSMB7 (9q33.3) / PDS5B (13q13.1)
PSMB7 (9q33.3) / PPP4R3A (14q32.12)PSMB7 (9q33.3) / PSMB7 (9q33.3)PSMB7 (9q33.3) / PTBP3 (9q32)
PSMB7 (9q33.3) / ZFP36 (19q13.2)SCAI (9q33.3) / PSMB7 (9q33.3)SMYD5 (2p13.2) / PSMB7 (9q33.3)
LONRF1 8p23.1 / PSMB7 9q33.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(8;9)(p23;q33) LONRF1/PSMB7

External links

Nomenclature
HGNC (Hugo)PSMB7   9544
Cards
Entrez_Gene (NCBI)PSMB7  5695  proteasome 20S subunit beta 7
AliasesZ
GeneCards (Weizmann)PSMB7
Ensembl hg19 (Hinxton)ENSG00000136930 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000136930 [Gene_View]  ENSG00000136930 [Sequence]  chr9:124353465-124415442 [Contig_View]  PSMB7 [Vega]
ICGC DataPortalENSG00000136930
TCGA cBioPortalPSMB7
AceView (NCBI)PSMB7
Genatlas (Paris)PSMB7
WikiGenes5695
SOURCE (Princeton)PSMB7
Genetics Home Reference (NIH)PSMB7
Genomic and cartography
GoldenPath hg38 (UCSC)PSMB7  -     chr9:124353465-124415442 -  9q33.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PSMB7  -     9q33.3   [Description]    (hg19-Feb_2009)
GoldenPathPSMB7 - 9q33.3 [CytoView hg19]  PSMB7 - 9q33.3 [CytoView hg38]
ImmunoBaseENSG00000136930
genome Data Viewer NCBIPSMB7 [Mapview hg19]  
OMIM604030   
Gene and transcription
Genbank (Entrez)AJ420455 AK056654 AK098757 AK223007 AK223356
RefSeq transcript (Entrez)NM_002799
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PSMB7
Alternative Splicing GalleryENSG00000136930
Gene ExpressionPSMB7 [ NCBI-GEO ]   PSMB7 [ EBI - ARRAY_EXPRESS ]   PSMB7 [ SEEK ]   PSMB7 [ MEM ]
Gene Expression Viewer (FireBrowse)PSMB7 [ Firebrowse - Broad ]
GenevisibleExpression of PSMB7 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5695
GTEX Portal (Tissue expression)PSMB7
Human Protein AtlasENSG00000136930-PSMB7 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99436   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99436  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99436
Splice isoforms : SwissVarQ99436
PhosPhoSitePlusQ99436
Domaine pattern : Prosite (Expaxy)PROTEASOME_BETA_1 (PS00854)    PROTEASOME_BETA_2 (PS51476)   
Domains : Interpro (EBI)Ntn_hydrolases_N    Pept_T1A_subB    Proteasome_beta7    Proteasome_bsu_C    Proteasome_bsu_CS    Proteasome_sua/b    Proteasome_suB-type   
Domain families : Pfam (Sanger)Pr_beta_C (PF12465)    Proteasome (PF00227)   
Domain families : Pfam (NCBI)pfam12465    pfam00227   
Conserved Domain (NCBI)PSMB7
DMDM Disease mutations5695
Blocks (Seattle)PSMB7
PDB (RSDB)4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    5VFO    5VFP    5VFQ    5VFR    5VFS    5VFT    5VFU    6HTB    6HTC    6HTD    6HTP    6HTR    6HUB    6HUC    6HUQ    6HUU    6HUV    6MSB    6MSD    6MSE    6MSG    6MSH    6MSJ    6MSK    6R70    6REY    6RGQ   
PDB Europe4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    5VFO    5VFP    5VFQ    5VFR    5VFS    5VFT    5VFU    6HTB    6HTC    6HTD    6HTP    6HTR    6HUB    6HUC    6HUQ    6HUU    6HUV    6MSB    6MSD    6MSE    6MSG    6MSH    6MSJ    6MSK    6R70    6REY    6RGQ   
PDB (PDBSum)4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    5VFO    5VFP    5VFQ    5VFR    5VFS    5VFT    5VFU    6HTB    6HTC    6HTD    6HTP    6HTR    6HUB    6HUC    6HUQ    6HUU    6HUV    6MSB    6MSD    6MSE    6MSG    6MSH    6MSJ    6MSK    6R70    6REY    6RGQ   
PDB (IMB)4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    5VFO    5VFP    5VFQ    5VFR    5VFS    5VFT    5VFU    6HTB    6HTC    6HTD    6HTP    6HTR    6HUB    6HUC    6HUQ    6HUU    6HUV    6MSB    6MSD    6MSE    6MSG    6MSH    6MSJ    6MSK    6R70    6REY    6RGQ   
Structural Biology KnowledgeBase4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    5VFO    5VFP    5VFQ    5VFR    5VFS    5VFT    5VFU    6HTB    6HTC    6HTD    6HTP    6HTR    6HUB    6HUC    6HUQ    6HUU    6HUV    6MSB    6MSD    6MSE    6MSG    6MSH    6MSJ    6MSK    6R70    6REY    6RGQ   
SCOP (Structural Classification of Proteins)4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    5VFO    5VFP    5VFQ    5VFR    5VFS    5VFT    5VFU    6HTB    6HTC    6HTD    6HTP    6HTR    6HUB    6HUC    6HUQ    6HUU    6HUV    6MSB    6MSD    6MSE    6MSG    6MSH    6MSJ    6MSK    6R70    6REY    6RGQ   
CATH (Classification of proteins structures)4R3O    4R67    5A0Q    5GJQ    5GJR    5L4G    5LE5    5LEX    5LEY    5LEZ    5LF0    5LF1    5LF3    5LF4    5LF6    5LF7    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    5VFO    5VFP    5VFQ    5VFR    5VFS    5VFT    5VFU    6HTB    6HTC    6HTD    6HTP    6HTR    6HUB    6HUC    6HUQ    6HUU    6HUV    6MSB    6MSD    6MSE    6MSG    6MSH    6MSJ    6MSK    6R70    6REY    6RGQ   
SuperfamilyQ99436
Human Protein Atlas [tissue]ENSG00000136930-PSMB7 [tissue]
Peptide AtlasQ99436
HPRD04940
IPIIPI00003217   IPI00908513   IPI00514549   
Protein Interaction databases
DIP (DOE-UCLA)Q99436
IntAct (EBI)Q99436
FunCoupENSG00000136930
BioGRIDPSMB7
STRING (EMBL)PSMB7
ZODIACPSMB7
Ontologies - Pathways
QuickGOQ99436
Ontology : AmiGOMAPK cascade  protein polyubiquitination  proteasome complex  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  endopeptidase activity  threonine-type endopeptidase activity  protein binding  extracellular region  nucleus  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  cytosol  proteasome core complex  proteasome core complex  regulation of cellular amino acid metabolic process  proteasomal protein catabolic process  proteasomal ubiquitin-independent protein catabolic process  negative regulation of G2/M transition of mitotic cell cycle  viral process  protein deubiquitination  proteasome core complex, beta-subunit complex  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  secretory granule lumen  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  proteasome-mediated ubiquitin-dependent protein catabolic process  neutrophil degranulation  regulation of mRNA stability  post-translational protein modification  T cell receptor signaling pathway  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  regulation of transcription from RNA polymerase II promoter in response to hypoxia  interleukin-1-mediated signaling pathway  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  regulation of mitotic cell cycle phase transition  regulation of hematopoietic stem cell differentiation  ficolin-1-rich granule lumen  
Ontology : EGO-EBIMAPK cascade  protein polyubiquitination  proteasome complex  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  endopeptidase activity  threonine-type endopeptidase activity  protein binding  extracellular region  nucleus  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  cytosol  proteasome core complex  proteasome core complex  regulation of cellular amino acid metabolic process  proteasomal protein catabolic process  proteasomal ubiquitin-independent protein catabolic process  negative regulation of G2/M transition of mitotic cell cycle  viral process  protein deubiquitination  proteasome core complex, beta-subunit complex  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  secretory granule lumen  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  proteasome-mediated ubiquitin-dependent protein catabolic process  neutrophil degranulation  regulation of mRNA stability  post-translational protein modification  T cell receptor signaling pathway  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  regulation of transcription from RNA polymerase II promoter in response to hypoxia  interleukin-1-mediated signaling pathway  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  regulation of mitotic cell cycle phase transition  regulation of hematopoietic stem cell differentiation  ficolin-1-rich granule lumen  
Pathways : KEGGProteasome   
NDEx NetworkPSMB7
Atlas of Cancer Signalling NetworkPSMB7
Wikipedia pathwaysPSMB7
Orthology - Evolution
OrthoDB5695
GeneTree (enSembl)ENSG00000136930
Phylogenetic Trees/Animal Genes : TreeFamPSMB7
HOGENOMQ99436
Homologs : HomoloGenePSMB7
Homology/Alignments : Family Browser (UCSC)PSMB7
Gene fusions - Rearrangements
Fusion : MitelmanLONRF1/PSMB7 [8p23.1/9q33.3]  
Fusion PortalLONRF1 8p23.1 PSMB7 9q33.3 SKCM
Fusion : QuiverPSMB7
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPSMB7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PSMB7
dbVarPSMB7
ClinVarPSMB7
1000_GenomesPSMB7 
Exome Variant ServerPSMB7
GNOMAD BrowserENSG00000136930
Varsome BrowserPSMB7
Genetic variants : HAPMAP5695
Genomic Variants (DGV)PSMB7 [DGVbeta]
DECIPHERPSMB7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPSMB7 
Mutations
ICGC Data PortalPSMB7 
TCGA Data PortalPSMB7 
Broad Tumor PortalPSMB7
OASIS PortalPSMB7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPSMB7  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPSMB7
Mutations and Diseases : HGMDPSMB7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PSMB7
DgiDB (Drug Gene Interaction Database)PSMB7
DoCM (Curated mutations)PSMB7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PSMB7 (select a term)
intoGenPSMB7
Cancer3DPSMB7(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604030   
Orphanet
DisGeNETPSMB7
MedgenPSMB7
Genetic Testing Registry PSMB7
NextProtQ99436 [Medical]
TSGene5695
GENETestsPSMB7
Target ValidationPSMB7
Huge Navigator PSMB7 [HugePedia]
snp3D : Map Gene to Disease5695
BioCentury BCIQPSMB7
ClinGenPSMB7
Clinical trials, drugs, therapy
Protein Interactions : CTD5695
Pharm GKB GenePA33889
Clinical trialPSMB7
Miscellaneous
canSAR (ICR)PSMB7 (select the gene name)
HarmonizomePSMB7
DataMed IndexPSMB7
Probes
Litterature
PubMed117 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePSMB7
EVEXPSMB7
GoPubMedPSMB7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jul 16 15:31:43 CEST 2020
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