PSPC1 (paraspeckle component 1)

2012-05-01  

Identity

HGNC
LOCATION
13q12.11
LOCUSID
ALIAS
PSP1
FUSION GENES

Other Information

Locus ID:

NCBI: 55269
MIM: 612408
HGNC: 20320
Ensembl: ENSG00000121390

Variants:

dbSNP: 55269
ClinVar: 55269
TCGA: ENSG00000121390
COSMIC: PSPC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000121390ENST00000338910Q8WXF1
ENSG00000121390ENST00000427943X6RDA4
ENSG00000121390ENST00000471658Q8WXF1
ENSG00000121390ENST00000471658A0A024RDP4
ENSG00000121390ENST00000492741Q8WXF1
ENSG00000121390ENST00000492741A0A024RDP4
ENSG00000121390ENST00000619300Q8WXF1
ENSG00000121390ENST00000635562A0A0U1RQF9

Expression (GTEx)

0
10
20
30
40
50
60

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
161480432005P54nrb forms a heterodimer with PSP1 that localizes to paraspeckles in an RNA-dependent manner.94
215323452011LSINCT5 is over expressed in breast and ovarian cancer and affects cellular proliferation.58
224161262012Structure of the heterodimer of human NONO and paraspeckle protein component 1 and analysis of its role in subnuclear body formation.54
295933262018PSPC1 mediates TGF-β1 autocrine signalling and Smad2/3 target switching to promote EMT, stemness and metastasis.27
294836552018RNA-dependent chromatin targeting of TET2 for endogenous retrovirus control in pluripotent stem cells.16
221020352011Crystallization of a paraspeckle protein PSPC1-NONO heterodimer.7
296621422018The Hepatitis Delta Virus accumulation requires paraspeckle components and affects NEAT1 level and PSP1 localization.6
295309792018Crystal structure of a SFPQ/PSPC1 heterodimer provides insights into preferential heterodimerization of human DBHS family proteins.4
282402512017Development of a pipeline for automated, high-throughput analysis of paraspeckle proteins reveals specific roles for importin α proteins.2
318440572019PSPC1-interchanged interactions with PTK6 and β-catenin synergize oncogenic subcellular translocations and tumor progression.2

Citation

Dessen P

PSPC1 (paraspeckle component 1)

Atlas Genet Cytogenet Oncol Haematol. 2012-05-01

Online version: http://atlasgeneticsoncology.org/gene/52703/pspc1