PTBP2 (polypyrimidine tract binding protein 2)

2013-11-01  

Identity

HGNC
PTBP2
LOCATION
1p21.3
LOCUSID
58155
ALIAS
PTBLP,brPTB,nPTB
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 58155
MIM: 608449
HGNC: 17662
Ensembl: ENSG00000117569

Variants:

dbSNP: 58155
ClinVar: 58155
TCGA: ENSG00000117569
COSMIC: PTBP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000117569ENST00000370197Q9UKA9
ENSG00000117569ENST00000370198Q9UKA9
ENSG00000117569ENST00000426398Q9UKA9
ENSG00000117569ENST00000609116Q9UKA9

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
250259662014Long non-coding RNA MALAT1 promotes tumour growth and metastasis in colorectal cancer through binding to SFPQ and releasing oncogene PTBP2 from SFPQ/PTBP2 complex.142
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
201601052010RNA looping by PTB: Evidence using FRET and NMR spectroscopy for a role in splicing repression.45
242640392013New insights into functional roles of the polypyrimidine tract-binding protein.37
212821122011Regulation of the mutually exclusive exons 8a and 8 in the CaV1.2 calcium channel transcript by polypyrimidine tract-binding protein.30
175484332007hnRNP I/PTB can antagonize the splicing repressor activity of SRp30c.25
276814242016PTBP1 and PTBP2 Repress Nonconserved Cryptic Exons.22
264165542015PTBP1 and PTBP2 impaired autoregulation of SRSF3 in cancer cells.17
231749042013BCR-ABL mediated repression of miR-223 results in the activation of MEF2C and PTBP2 in chronic myeloid leukemia.9
266576382016Human polypyrimidine tract-binding protein interacts with mitochondrial tRNA(Thr) in the cytosol.6

Citation

Dessen P

PTBP2 (polypyrimidine tract binding protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2013-11-01

Online version: http://atlasgeneticsoncology.org/gene/53551/ptbp2