PTGDR (prostaglandin D2 receptor)

2014-09-01 Affiliation

Identity

HGNC

PTGDR

LOCATION

14q22.1

LOCUSID

5729

ALIAS

AS1,ASRT1,DP,DP1,PTGDR1

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5729
MIM: 604687
HGNC: 9591
Ensembl: ENSG00000168229

Variants:

dbSNP: 5729
ClinVar: 5729
TCGA: ENSG00000168229
COSMIC: PTGDR

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000168229	ENST00000306051	Q13258
ENSG00000168229	ENST00000553372	Q13258

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Eicosanoid ligand-binding receptors	REACTOME	R-HSA-391903
Prostanoid ligand receptors	REACTOME	R-HSA-391908
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (s) signalling events	REACTOME	R-HSA-418555

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA166129564	laropiprant	Chemical	MultilinkAnnotation	associated			26226939
PA175	GNAS	Gene	Pathway	associated			20938371

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
15749909	2005	Activation of the prostaglandin D2 receptor DP2/CRTH2 increases allergic inflammation in mouse.	66
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
17965752	2008	The roles of the prostaglandin D(2) receptors DP(1) and CRTH2 in promoting allergic responses.	39
19247692	2009	Analyses of associations with asthma in four asthma population samples from Canada and Australia.	39
19264973	2009	Assessing the reproducibility of asthma candidate gene associations, using genome-wide data.	36
20237496	2010	New genetic associations detected in a host response study to hepatitis B vaccine.	27
12895603	2003	The role of mast cells in asthma.	23
17878378	2007	The role of the prostaglandin D2 receptor, DP, in eosinophil trafficking.	23
18797183	2008	Correlation between the prostaglandin D(2)/E(2) ratio in nasal polyps and the recalcitrant pathophysiology of chronic rhinosinusitis associated with bronchial asthma.	23

Citation

Dessen P

PTGDR (prostaglandin D2 receptor)

Atlas Genet Cytogenet Oncol Haematol. 2014-09-01

Online version: http://atlasgeneticsoncology.org/gene/54851/ptgdr