PTGER4 (prostaglandin E receptor 4)

2007-02-01 Affiliation

Identity

HGNC

PTGER4

LOCATION

5p13.1

LOCUSID

5734

ALIAS

EP4,EP4R

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5734
MIM: 601586
HGNC: 9596
Ensembl: ENSG00000171522

Variants:

dbSNP: 5734
ClinVar: 5734
TCGA: ENSG00000171522
COSMIC: PTGER4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000171522	ENST00000302472	P35408

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Pathways in cancer	KEGG	hsa05200
Inflammatory mediator regulation of TRP channels	KEGG	hsa04750
Inflammatory mediator regulation of TRP channels	KEGG	ko04750
Renin secretion	KEGG	hsa04924
Renin secretion	KEGG	ko04924
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Eicosanoid ligand-binding receptors	REACTOME	R-HSA-391903
Prostanoid ligand receptors	REACTOME	R-HSA-391908
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (s) signalling events	REACTOME	R-HSA-418555

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA446108	Colorectal Neoplasms	Disease	ClinicalAnnotation	associated		PD	23778325
PA448871	celecoxib	Chemical	ClinicalAnnotation	associated		PD	23778325

References

Pubmed ID	Year	Title	Citations
17447842	2007	Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4.	183
19273625	2009	Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling.	157
12149218	2002	Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells.	135
22037551	2011	A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1.	106
12566441	2003	Prostaglandin E2 induced functional expression of early growth response factor-1 by EP4, but not EP2, prostanoid receptors via the phosphatidylinositol 3-kinase and extracellular signal-regulated kinases.	91
11782353	2002	Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis.	89
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
19879194	2009	Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score.	80
12215436	2002	Prostaglandin E2 suppresses chemokine production in human macrophages through the EP4 receptor.	77
21081469	2011	NF-κB targets miR-16 and miR-21 in gastric cancer: involvement of prostaglandin E receptors.	64

Citation

Dessen P

PTGER4 (prostaglandin E receptor 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43737/ptger4