PTGES (prostaglandin E synthase)

2003-02-01 Affiliation

Identity

HGNC

PTGES

LOCATION

9q34.11

LOCUSID

9536

ALIAS

MGST-IV,MGST1-L1,MGST1L1,MPGES,PGES,PIG12,PP102,PP1294,TP53I12,mPGES-1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 9536
MIM: 605172
HGNC: 9599
Ensembl: ENSG00000148344

Variants:

dbSNP: 9536
ClinVar: 9536
TCGA: ENSG00000148344
COSMIC: PTGES

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000148344	ENST00000340607	O14684

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Arachidonic acid metabolism	KEGG	ko00590
Arachidonic acid metabolism	KEGG	hsa00590
Metabolic pathways	KEGG	hsa01100
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Arachidonic acid metabolism	REACTOME	R-HSA-2142753
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	REACTOME	R-HSA-2162123

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA446108	Colorectal Neoplasms	Disease	ClinicalAnnotation	associated		PD	23778325
PA448871	celecoxib	Chemical	ClinicalAnnotation	associated		PD	23778325

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
12835322	2003	Cellular prostaglandin E2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2.	81
15234907	2004	Cigarette smoke induces cyclooxygenase-2 and microsomal prostaglandin E2 synthase in human lung fibroblasts: implications for lung inflammation and cancer.	60
12626523	2003	Potential role of microsomal prostaglandin E synthase-1 in tumorigenesis.	49
15188353	2004	Expression of microsomal prostaglandin E synthase 1 in rheumatoid arthritis synovium.	40
20042640	2010	Hypoxia activates the cyclooxygenase-2-prostaglandin E synthase axis.	36
12672824	2003	Human microsomal prostaglandin E synthase-1: purification, functional characterization, and projection structure determination.	35
18818748	2008	Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants.	31
19527514	2009	Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants.	31
20628624	2010	Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".	29

Citation

Dessen P

PTGES (prostaglandin E synthase)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41895/ptges