Identity
HGNC
LOCATION
9q34.11
LOCUSID
ALIAS
MGST-IV,MGST1-L1,MGST1L1,MPGES,PGES,PIG12,PP102,PP1294,TP53I12,mPGES-1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9536
MIM: 605172
HGNC: 9599
Ensembl: ENSG00000148344
Variants:
dbSNP: 9536
ClinVar: 9536
TCGA: ENSG00000148344
COSMIC: PTGES
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000148344 | ENST00000340607 | O14684 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA446108 | Colorectal Neoplasms | Disease | ClinicalAnnotation | associated | PD | 23778325 | |
| PA448871 | celecoxib | Chemical | ClinicalAnnotation | associated | PD | 23778325 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37108468 | 2023 | PTGES Expression Is Associated with Metabolic and Immune Reprogramming in Pancreatic Ductal Adenocarcinoma. | 0 |
| 37358009 | 2023 | Targeting PTGES/PGE2 axis enhances sensitivity of colorectal cancer cells to 5-fluorouracil. | 0 |
| 37108468 | 2023 | PTGES Expression Is Associated with Metabolic and Immune Reprogramming in Pancreatic Ductal Adenocarcinoma. | 0 |
| 37358009 | 2023 | Targeting PTGES/PGE2 axis enhances sensitivity of colorectal cancer cells to 5-fluorouracil. | 0 |
| 33574423 | 2021 | Clinical data mining reveals analgesic effects of lapatinib in cancer patients. | 2 |
| 33574423 | 2021 | Clinical data mining reveals analgesic effects of lapatinib in cancer patients. | 2 |
| 30423474 | 2019 | Microsomal prostaglandin E synthase-1 is a critical factor in dopaminergic neurodegeneration in Parkinson's disease. | 10 |
| 30730082 | 2019 | Prostaglandins in androgenetic alopecia in 12 men and four female. | 5 |
| 30814036 | 2019 | MPGES-1 derived PGE2 inhibits cell migration by regulating ARP2/3 in the pathogenesis of Hirschsprung disease. | 2 |
| 30423474 | 2019 | Microsomal prostaglandin E synthase-1 is a critical factor in dopaminergic neurodegeneration in Parkinson's disease. | 10 |
| 30730082 | 2019 | Prostaglandins in androgenetic alopecia in 12 men and four female. | 5 |
| 30814036 | 2019 | MPGES-1 derived PGE2 inhibits cell migration by regulating ARP2/3 in the pathogenesis of Hirschsprung disease. | 2 |
| 29273868 | 2018 | Involvement of TLR3-Dependent PGES Expression in Immunosuppression by Human Bone Marrow Mesenchymal Stem Cells. | 14 |
| 29804818 | 2018 | Inhibition of Microsomal Prostaglandin E Synthase-1 in Cancer-Associated Fibroblasts Suppresses Neuroblastoma Tumor Growth. | 39 |
| 29898737 | 2018 | Down-regulation of microsomal prostaglandin E2 synthase-1 in the infrapatellar fat pad of osteoarthritis patients with hypercholesterolemia. | 1 |
Citation
Dessen P
PTGES (prostaglandin E synthase)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/41895/ptges
