PTGES2 (prostaglandin E synthase 2)

2009-09-01  

Identity

HGNC
PTGES2
LOCATION
9q34.11
LOCUSID
80142
ALIAS
C9orf15,GBF-1,GBF1,PGES2,mPGES-2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 80142
MIM: 608152
HGNC: 17822
Ensembl: ENSG00000148334

Variants:

dbSNP: 80142
ClinVar: 80142
TCGA: ENSG00000148334
COSMIC: PTGES2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000148334ENST00000277462A6NHH0
ENSG00000148334ENST00000338961Q9H7Z7
ENSG00000148334ENST00000449878X6RJ95
ENSG00000148334ENST00000617202A6NHH0

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Arachidonic acid metabolismKEGGko00590
Arachidonic acid metabolismKEGGhsa00590
Metabolic pathwaysKEGGhsa01100
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Arachidonic acid metabolismREACTOMER-HSA-2142753
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)REACTOMER-HSA-2162123
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
118472192002Up-regulation of prostaglandin E2 synthesis by interleukin-1beta in human orbital fibroblasts involves coordinate induction of prostaglandin-endoperoxide H synthase-2 and glutathione-dependent prostaglandin E2 synthase expression.34
176971492007Prostaglandin metabolism in human hair follicle.21
193363702009Determination of genetic predisposition to patent ductus arteriosus in preterm infants.17
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
194126212009Microsomal prostaglandin E synthase protein levels correlate with prognosis in colorectal cancer patients.13
244676032014Genetic variation in the prostaglandin E2 pathway is associated with primary graft dysfunction.13
196646212010Microsomal prostaglandin E synthase-2: cellular distribution and expression in Alzheimer's disease.11
167143292006Alpha-tocopheryl succinate, in contrast to alpha-tocopherol and alpha-tocopheryl acetate, inhibits prostaglandin E2 production in human lung epithelial cells.10
193479952009The terminal prostaglandin synthases mPGES-1, mPGES-2, and cPGES are all overexpressed in human gliomas.10
128046042003Essential 110Cys in active site of membrane-associated prostaglandin E synthase-2.9

Citation

Dessen P

PTGES2 (prostaglandin E synthase 2)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01

Online version: http://atlasgeneticsoncology.org/gene/51067/ptges2