Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PTGES3 (prostaglandin E synthase 3)

Identity

Alias_namesprostaglandin E synthase 3 (cytosolic)
Alias_symbol (synonym)p23
TEBP
cPGES
Other aliasP23
HGNC (Hugo) PTGES3
LocusID (NCBI) 10728
Atlas_Id 45663
Location 12q13.3  [Link to chromosome band 12q13]
Location_base_pair Starts at 56663341 and ends at 56688408 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AHCYL2 (7q32.1) / PTGES3 (12q13.3)ATP5B (12q13.3) / PTGES3 (12q13.3)PTGES3 (12q13.3) / NACA (12q13.3)
PTGES3 (12q13.3) / PTPRB (12q15)TOR1A (9q34.11) / PTGES3 (12q13.3)PTGES3 12q13.3 / NACA 12q13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  PTGES3/NACA (12q13)
t(12;12)(q13;q15) PTGES3/PTPRB

External links

Nomenclature
HGNC (Hugo)PTGES3   16049
Cards
Entrez_Gene (NCBI)PTGES3  10728  prostaglandin E synthase 3
AliasesP23; TEBP; cPGES
GeneCards (Weizmann)PTGES3
Ensembl hg19 (Hinxton)ENSG00000110958 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000110958 [Gene_View]  ENSG00000110958 [Sequence]  chr12:56663341-56688408 [Contig_View]  PTGES3 [Vega]
ICGC DataPortalENSG00000110958
TCGA cBioPortalPTGES3
AceView (NCBI)PTGES3
Genatlas (Paris)PTGES3
WikiGenes10728
SOURCE (Princeton)PTGES3
Genetics Home Reference (NIH)PTGES3
Genomic and cartography
GoldenPath hg38 (UCSC)PTGES3  -     chr12:56663341-56688408 -  12q13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PTGES3  -     12q13.3   [Description]    (hg19-Feb_2009)
GoldenPathPTGES3 - 12q13.3 [CytoView hg19]  PTGES3 - 12q13.3 [CytoView hg38]
ImmunoBaseENSG00000110958
Mapping of homologs : NCBIPTGES3 [Mapview hg19]  PTGES3 [Mapview hg38]
OMIM607061   
Gene and transcription
Genbank (Entrez)AK098214 AK291945 AK293139 AK295208 AK298147
RefSeq transcript (Entrez)NM_001282601 NM_001282602 NM_001282603 NM_001282604 NM_001282605 NM_006601
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PTGES3
Cluster EST : UnigeneHs.50425 [ NCBI ]
CGAP (NCI)Hs.50425
Alternative Splicing GalleryENSG00000110958
Gene ExpressionPTGES3 [ NCBI-GEO ]   PTGES3 [ EBI - ARRAY_EXPRESS ]   PTGES3 [ SEEK ]   PTGES3 [ MEM ]
Gene Expression Viewer (FireBrowse)PTGES3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10728
GTEX Portal (Tissue expression)PTGES3
Human Protein AtlasENSG00000110958-PTGES3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15185   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15185  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15185
Splice isoforms : SwissVarQ15185
PhosPhoSitePlusQ15185
Domaine pattern : Prosite (Expaxy)CS (PS51203)   
Domains : Interpro (EBI)CS_dom    HSP20-like_chaperone   
Domain families : Pfam (Sanger)CS (PF04969)   
Domain families : Pfam (NCBI)pfam04969   
Conserved Domain (NCBI)PTGES3
DMDM Disease mutations10728
Blocks (Seattle)PTGES3
PDB (RSDB)1EJF    1LG0   
PDB Europe1EJF    1LG0   
PDB (PDBSum)1EJF    1LG0   
PDB (IMB)1EJF    1LG0   
Structural Biology KnowledgeBase1EJF    1LG0   
SCOP (Structural Classification of Proteins)1EJF    1LG0   
CATH (Classification of proteins structures)1EJF    1LG0   
SuperfamilyQ15185
Human Protein Atlas [tissue]ENSG00000110958-PTGES3 [tissue]
Peptide AtlasQ15185
HPRD06138
IPIIPI00015029   IPI00789101   IPI00910005   IPI00910575   IPI00908647   IPI00790462   
Protein Interaction databases
DIP (DOE-UCLA)Q15185
IntAct (EBI)Q15185
FunCoupENSG00000110958
BioGRIDPTGES3
STRING (EMBL)PTGES3
ZODIACPTGES3
Ontologies - Pathways
QuickGOQ15185
Ontology : AmiGOtelomere maintenance  chromosome, telomeric region  prostaglandin biosynthetic process  prostaglandin biosynthetic process  telomerase activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  telomerase holoenzyme complex  cytoplasm  cytosol  cytosol  cytosol  protein folding  xenobiotic metabolic process  telomere maintenance via telomerase  telomere maintenance via telomerase  telomere maintenance via telomerase  signal transduction  cyclooxygenase pathway  protein-containing complex  positive regulation of phosphorylation  prostaglandin-E synthase activity  prostaglandin-E synthase activity  protein stabilization  unfolded protein binding  chaperone cofactor-dependent protein refolding  chaperone binding  chaperone-mediated protein complex assembly  chaperone-mediated protein complex assembly  Hsp90 protein binding  Hsp90 protein binding  positive regulation of telomerase activity  positive regulation of telomerase activity  DNA polymerase binding  chaperone complex  regulation of cellular response to heat  telomerase holoenzyme complex assembly  telomerase holoenzyme complex assembly  
Ontology : EGO-EBItelomere maintenance  chromosome, telomeric region  prostaglandin biosynthetic process  prostaglandin biosynthetic process  telomerase activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  telomerase holoenzyme complex  cytoplasm  cytosol  cytosol  cytosol  protein folding  xenobiotic metabolic process  telomere maintenance via telomerase  telomere maintenance via telomerase  telomere maintenance via telomerase  signal transduction  cyclooxygenase pathway  protein-containing complex  positive regulation of phosphorylation  prostaglandin-E synthase activity  prostaglandin-E synthase activity  protein stabilization  unfolded protein binding  chaperone cofactor-dependent protein refolding  chaperone binding  chaperone-mediated protein complex assembly  chaperone-mediated protein complex assembly  Hsp90 protein binding  Hsp90 protein binding  positive regulation of telomerase activity  positive regulation of telomerase activity  DNA polymerase binding  chaperone complex  regulation of cellular response to heat  telomerase holoenzyme complex assembly  telomerase holoenzyme complex assembly  
Pathways : KEGGArachidonic acid metabolism   
NDEx NetworkPTGES3
Atlas of Cancer Signalling NetworkPTGES3
Wikipedia pathwaysPTGES3
Orthology - Evolution
OrthoDB10728
GeneTree (enSembl)ENSG00000110958
Phylogenetic Trees/Animal Genes : TreeFamPTGES3
HOGENOMQ15185
Homologs : HomoloGenePTGES3
Homology/Alignments : Family Browser (UCSC)PTGES3
Gene fusions - Rearrangements
Fusion : MitelmanPTGES3/NACA [12q13.3/12q13.3]  
Fusion : MitelmanPTGES3/PTPRB [12q13.3/12q15]  [t(12;12)(q13;q15)]  
Fusion PortalPTGES3 12q13.3 NACA 12q13.3 HNSC
Fusion : QuiverPTGES3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTGES3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTGES3
dbVarPTGES3
ClinVarPTGES3
1000_GenomesPTGES3 
Exome Variant ServerPTGES3
ExAC (Exome Aggregation Consortium)ENSG00000110958
GNOMAD BrowserENSG00000110958
Varsome BrowserPTGES3
Genetic variants : HAPMAP10728
Genomic Variants (DGV)PTGES3 [DGVbeta]
DECIPHERPTGES3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPTGES3 
Mutations
ICGC Data PortalPTGES3 
TCGA Data PortalPTGES3 
Broad Tumor PortalPTGES3
OASIS PortalPTGES3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTGES3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPTGES3
Mutations and Diseases : HGMDPTGES3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PTGES3
DgiDB (Drug Gene Interaction Database)PTGES3
DoCM (Curated mutations)PTGES3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PTGES3 (select a term)
intoGenPTGES3
Cancer3DPTGES3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607061   
Orphanet
DisGeNETPTGES3
MedgenPTGES3
Genetic Testing Registry PTGES3
NextProtQ15185 [Medical]
TSGene10728
GENETestsPTGES3
Target ValidationPTGES3
Huge Navigator PTGES3 [HugePedia]
snp3D : Map Gene to Disease10728
BioCentury BCIQPTGES3
ClinGenPTGES3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10728
Chemical/Pharm GKB GenePA142671118
Clinical trialPTGES3
Miscellaneous
canSAR (ICR)PTGES3 (select the gene name)
DataMed IndexPTGES3
Probes
Litterature
PubMed147 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePTGES3
EVEXPTGES3
GoPubMedPTGES3
iHOPPTGES3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 18:03:15 CET 2019
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