PTGES3 (prostaglandin E synthase 3)

2007-02-01  

Identity

HGNC
LOCATION
12q13.3
LOCUSID
ALIAS
P23,TEBP,cPGES
FUSION GENES

Other Information

Locus ID:

NCBI: 10728
MIM: 607061
HGNC: 16049
Ensembl: ENSG00000110958

Variants:

dbSNP: 10728
ClinVar: 10728
TCGA: ENSG00000110958
COSMIC: PTGES3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110958ENST00000262033Q15185
ENSG00000110958ENST00000262033A0A024RB32
ENSG00000110958ENST00000414274Q15185
ENSG00000110958ENST00000436399Q15185
ENSG00000110958ENST00000448157Q15185
ENSG00000110958ENST00000456859B4DDC6
ENSG00000110958ENST00000614328A0A087WYT3

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Arachidonic acid metabolismKEGGko00590
Arachidonic acid metabolismKEGGhsa00590
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Arachidonic acid metabolismREACTOMER-HSA-2142753
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)REACTOMER-HSA-2162123
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Cellular responses to stressREACTOMER-HSA-2262752
Cellular response to heat stressREACTOMER-HSA-3371556
HSF1 activationREACTOMER-HSA-3371511
HSF1-dependent transactivationREACTOMER-HSA-3371571
Attenuation phaseREACTOMER-HSA-3371568
Aryl hydrocarbon receptor signallingREACTOMER-HSA-8937144

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
120774192002Disassembly of transcriptional regulatory complexes by molecular chaperones.146
164034132006The co-chaperone p23 arrests the Hsp90 ATPase cycle to trap client proteins.73
192548102009The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids.39
211837202011N-terminal domain of human Hsp90 triggers binding to the cochaperone p23.38
145079102003The hsp90 cochaperone p23 is the limiting component of the multiprotein hsp90/hsp70-based chaperone system in vivo where it acts to stabilize the client protein: hsp90 complex.32
199963132010Celastrol inhibits Hsp90 chaperoning of steroid receptors by inducing fibrillization of the Co-chaperone p23.32
168097592006The cochaperone p23 differentially regulates estrogen receptor target genes and promotes tumor cell adhesion and invasion.22
234130292013Prolyl hydroxylase domain protein 2 (PHD2) binds a Pro-Xaa-Leu-Glu motif, linking it to the heat shock protein 90 pathway.22
176971492007Prostaglandin metabolism in human hair follicle.21
197519632010Curcumin inhibits nuclear localization of telomerase by dissociating the Hsp90 co-chaperone p23 from hTERT.21

Citation

Dessen P

PTGES3 (prostaglandin E synthase 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45663/ptges3