PTGS1 (prostaglandin-endoperoxide synthase 1)

2003-02-01  

Identity

HGNC
LOCATION
9q33.2
LOCUSID
ALIAS
COX1,COX3,PCOX1,PES-1,PGG/HS,PGHS-1,PGHS1,PHS1,PTGHS
FUSION GENES

Other Information

Locus ID:

NCBI: 5742
MIM: 176805
HGNC: 9604
Ensembl: ENSG00000095303

Variants:

dbSNP: 5742
ClinVar: 5742
TCGA: ENSG00000095303
COSMIC: PTGS1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000095303ENST00000223423P23219
ENSG00000095303ENST00000362012P23219
ENSG00000095303ENST00000373698P23219
ENSG00000095303ENST00000426608X6RJD6
ENSG00000095303ENST00000540753P23219
ENSG00000095303ENST00000619306A0A087X296
ENSG00000095303ENST00000643810A0A2R8YDM0
ENSG00000095303ENST00000647067A0A2R8Y6S0

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Arachidonic acid metabolismKEGGko00590
Arachidonic acid metabolismKEGGhsa00590
Metabolic pathwaysKEGGhsa01100
Serotonergic synapseKEGGhsa04726
Platelet activationKEGGhsa04611
Regulation of lipolysis in adipocytesKEGGhsa04923
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Arachidonic acid metabolismREACTOMER-HSA-2142753
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)REACTOMER-HSA-2162123
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
COX reactionsREACTOMER-HSA-140180

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10384antiinflammatory and antirheumatic products, non-steroidsChemicalPathwayassociated22336956
PA164712462Antiinflammatory agents, non-steroidsChemicalClinicalAnnotationassociatedPD20538124
PA164774763latanoprostChemicalClinicalAnnotationassociatedPD25339146
PA165108401Acute coronary syndromeDiseaseClinicalAnnotationassociatedPD20538124
PA166129560major adverse cardiac events (mace)DiseaseClinicalAnnotationassociatedPD
PA443796Coronary Artery DiseaseDiseaseClinicalAnnotationassociatedPD16493486, 22940005
PA444282Glaucoma, Open-AngleDiseaseClinicalAnnotationassociatedPD25339146
PA445019Myocardial InfarctionDiseaseClinicalAnnotationassociatedPD16493486, 22940005
PA448497aspirinChemicalClinicalAnnotation, PathwayassociatedPD16493486, 20938371, 22940005
PA449053clopidogrelChemicalClinicalAnnotationassociatedPD22940005
PA449957ibuprofenChemicalPathwayassociated25502615

References

Pubmed IDYearTitleCitations
122423292002COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression.225
81214891994The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1.166
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
128353222003Cellular prostaglandin E2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2.81
186572302009Cyclooxygenase in normal human tissues--is COX-1 really a constitutive isoform, and COX-2 an inducible isoform?42
185118502008Angiogenic function of prostacyclin biosynthesis in human endothelial progenitor cells.39
166785432006Genetically mediated interindividual variation in analgesic responses to cyclooxygenase inhibitory drugs.36
206738682010A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).36
186361242008Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma.32
186766802008Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.32

Citation

Dessen P

PTGS1 (prostaglandin-endoperoxide synthase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41896/ptgs1