Identity
HGNC
LOCATION
1p35.2
LOCUSID
ALIAS
HH13,HH7-2,HU-PP-1,OV-1,PRL-2,PRL2,PTP4A,PTPCAAX2,ptp-IV1a,ptp-IV1b
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 8073
MIM: 601584
HGNC: 9635
Ensembl: ENSG00000184007
Variants:
dbSNP: 8073
ClinVar: 8073
TCGA: ENSG00000184007
COSMIC: PTP4A2
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Metabolism of proteins | REACTOME | R-HSA-392499 |
| Post-translational protein modification | REACTOME | R-HSA-597592 |
| RAB geranylgeranylation | REACTOME | R-HSA-8873719 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 32733084 | 2020 | A FRET-based screening method to detect potential inhibitors of the binding of CNNM3 to PRL2. | 4 |
| 32788364 | 2020 | Mechanism of PRL2 phosphatase-mediated PTEN degradation and tumorigenesis. | 17 |
| 32733084 | 2020 | A FRET-based screening method to detect potential inhibitors of the binding of CNNM3 to PRL2. | 4 |
| 32788364 | 2020 | Mechanism of PRL2 phosphatase-mediated PTEN degradation and tumorigenesis. | 17 |
| 30718434 | 2019 | Magnesium-sensitive upstream ORF controls PRL phosphatase expression to mediate energy metabolism. | 33 |
| 30718434 | 2019 | Magnesium-sensitive upstream ORF controls PRL phosphatase expression to mediate energy metabolism. | 33 |
| 27872499 | 2017 | Phosphatase PRL2 promotes oncogenic NOTCH1-Induced T-cell leukemia. | 8 |
| 28220038 | 2017 | Phosphatase PRL2 promotes AML1-ETO-induced acute myeloid leukemia. | 5 |
| 27872499 | 2017 | Phosphatase PRL2 promotes oncogenic NOTCH1-Induced T-cell leukemia. | 8 |
| 28220038 | 2017 | Phosphatase PRL2 promotes AML1-ETO-induced acute myeloid leukemia. | 5 |
| 25193986 | 2014 | MiR-29c mediates epithelial-to-mesenchymal transition in human colorectal carcinoma metastasis via PTP4A and GNA13 regulation of β-catenin signaling. | 54 |
| 25193986 | 2014 | MiR-29c mediates epithelial-to-mesenchymal transition in human colorectal carcinoma metastasis via PTP4A and GNA13 regulation of β-catenin signaling. | 54 |
| 22413991 | 2013 | Molecular mechanisms of the PRL phosphatases. | 65 |
| 23362275 | 2013 | Thioredoxin-related protein 32 (TRP32) specifically reduces oxidized phosphatase of regenerating liver (PRL). | 16 |
| 23568563 | 2013 | Protein tyrosine phosphatase 4A2 expression predicts overall and disease-free survival of human breast cancer and is associated with estrogen and progestin receptor status. | 9 |
Citation
Dessen P
PTP4A2 (protein tyrosine phosphatase 4A2)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/41907/ptp4a2
