PTP4A2 (protein tyrosine phosphatase 4A2)

2003-02-01 Affiliation

Identity

HGNC

PTP4A2

LOCATION

1p35.2

LOCUSID

8073

ALIAS

HH13,HH7-2,HU-PP-1,OV-1,PRL-2,PRL2,PTP4A,PTPCAAX2,ptp-IV1a,ptp-IV1b

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 8073
MIM: 601584
HGNC: 9635
Ensembl: ENSG00000184007

Variants:

dbSNP: 8073
ClinVar: 8073
TCGA: ENSG00000184007
COSMIC: PTP4A2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000184007	ENST00000457805	Q12974
ENSG00000184007	ENST00000468531	E9PMY3
ENSG00000184007	ENST00000470404	E9PRR9
ENSG00000184007	ENST00000528253	E9PJC0
ENSG00000184007	ENST00000532001	E9PML8
ENSG00000184007	ENST00000534796	E9PL34
ENSG00000184007	ENST00000602683	Q12974
ENSG00000184007	ENST00000602725	Q12974
ENSG00000184007	ENST00000626355	E9PML8
ENSG00000184007	ENST00000627328	E9PJC0
ENSG00000184007	ENST00000647444	Q12974
ENSG00000184007	ENST00000649841	Q12974

Expression (GTEx)

100

150

200

250

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
RAB geranylgeranylation	REACTOME	R-HSA-8873719

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
22413991	2013	Molecular mechanisms of the PRL phosphatases.	47
16832410	2006	Expression and prognostic impact of the protein tyrosine phosphatases PRL-1, PRL-2, and PRL-3 in breast cancer.	37
25193986	2014	MiR-29c mediates epithelial-to-mesenchymal transition in human colorectal carcinoma metastasis via PTP4A and GNA13 regulation of β-catenin signaling.	35
14643450	2003	Enhanced cell cycle progression and down regulation of p21(Cip1/Waf1) by PRL tyrosine phosphatases.	29
20841483	2010	Overexpression of the protein tyrosine phosphatase PRL-2 correlates with breast tumor formation and progression.	27
16957164	2006	Cellular localization of PRL-1 and PRL-2 gene expression in normal adult human tissues.	18
17440740	2007	Expression of the human phosphatases of regenerating liver (PRLs) in colonic adenocarcinoma and its correlation with lymph node metastasis.	18
21765462	2012	Metastasis-associated phosphatase PRL-2 regulates tumor cell migration and invasion.	14
23362275	2013	Thioredoxin-related protein 32 (TRP32) specifically reduces oxidized phosphatase of regenerating liver (PRL).	10
23568563	2013	Protein tyrosine phosphatase 4A2 expression predicts overall and disease-free survival of human breast cancer and is associated with estrogen and progestin receptor status.	6

Citation

Dessen P

PTP4A2 (protein tyrosine phosphatase 4A2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41907/ptp4a2