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PTP4A3 (protein tyrosine phosphatase type IVA, member 3)

Identity

Other namesPRL-3
PRL-R
PRL3
HGNC (Hugo) PTP4A3
LocusID (NCBI) 11156
Atlas_Id 41908
Location 8q24.3
Location_base_pair Starts at 142431488 and ends at 142442554 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PTP4A3 (8q24.3) / PTP4A3 (8q24.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PTP4A3   9636
Cards
Entrez_Gene (NCBI)PTP4A3  11156  protein tyrosine phosphatase type IVA, member 3
GeneCards (Weizmann)PTP4A3
Ensembl hg19 (Hinxton)ENSG00000184489 [Gene_View]  chr8:142431488-142442554 [Contig_View]  PTP4A3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000184489 [Gene_View]  chr8:142431488-142442554 [Contig_View]  PTP4A3 [Vega]
ICGC DataPortalENSG00000184489
TCGA cBioPortalPTP4A3
AceView (NCBI)PTP4A3
Genatlas (Paris)PTP4A3
WikiGenes11156
SOURCE (Princeton)PTP4A3
Genomic and cartography
GoldenPath hg19 (UCSC)PTP4A3  -     chr8:142431488-142442554 +  8q24.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PTP4A3  -     8q24.3   [Description]    (hg38-Dec_2013)
EnsemblPTP4A3 - 8q24.3 [CytoView hg19]  PTP4A3 - 8q24.3 [CytoView hg38]
Mapping of homologs : NCBIPTP4A3 [Mapview hg19]  PTP4A3 [Mapview hg38]
OMIM606449   
Gene and transcription
Genbank (Entrez)AF041434 AI742376 AJ276554 AK311257 BC003105
RefSeq transcript (Entrez)NM_007079 NM_032611
RefSeq genomic (Entrez)NC_000008 NC_018919 NT_008046 NT_187574 NW_004929340
Consensus coding sequences : CCDS (NCBI)PTP4A3
Cluster EST : UnigeneHs.744870 [ NCBI ]
CGAP (NCI)Hs.744870
Alternative Splicing : Fast-db (Paris)GSHG0033563
Alternative Splicing GalleryENSG00000184489
Gene ExpressionPTP4A3 [ NCBI-GEO ]   PTP4A3 [ EBI - ARRAY_EXPRESS ]   PTP4A3 [ SEEK ]   PTP4A3 [ MEM ]
Gene Expression Viewer (FireBrowse)PTP4A3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)11156
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75365 (Uniprot)
NextProtO75365  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75365
Splice isoforms : SwissVarO75365 (Swissvar)
Catalytic activity : Enzyme3.1.3.48 [ Enzyme-Expasy ]   3.1.3.483.1.3.48 [ IntEnz-EBI ]   3.1.3.48 [ BRENDA ]   3.1.3.48 [ KEGG ]   
PhosPhoSitePlusO75365
Domaine pattern : Prosite (Expaxy)TYR_PHOSPHATASE_2 (PS50056)   
Domains : Interpro (EBI)Dual-sp_phosphatase_cat-dom    Prot-tyrosine_phosphatase-like    TYR_PHOSPHATASE_dom   
Domain families : Pfam (Sanger)DSPc (PF00782)   
Domain families : Pfam (NCBI)pfam00782   
DMDM Disease mutations11156
Blocks (Seattle)PTP4A3
PDB (SRS)1R6H    1V3A    2MBC   
PDB (PDBSum)1R6H    1V3A    2MBC   
PDB (IMB)1R6H    1V3A    2MBC   
PDB (RSDB)1R6H    1V3A    2MBC   
Structural Biology KnowledgeBase1R6H    1V3A    2MBC   
SCOP (Structural Classification of Proteins)1R6H    1V3A    2MBC   
CATH (Classification of proteins structures)1R6H    1V3A    2MBC   
SuperfamilyO75365
Human Protein AtlasENSG00000184489
Peptide AtlasO75365
HPRD05922
IPIIPI00289328   IPI00026647   IPI00217075   IPI00983444   IPI00982778   
Protein Interaction databases
DIP (DOE-UCLA)O75365
IntAct (EBI)O75365
FunCoupENSG00000184489
BioGRIDPTP4A3
STRING (EMBL)PTP4A3
ZODIACPTP4A3
Ontologies - Pathways
QuickGOO75365
Ontology : AmiGOprenylated protein tyrosine phosphatase activity  nucleus  cytoplasm  early endosome  plasma membrane  Notch signaling pathway  protein tyrosine/serine/threonine phosphatase activity  peptidyl-tyrosine dephosphorylation  peptidyl-tyrosine dephosphorylation  positive regulation of vascular permeability  endothelial cell migration  regulation of vascular endothelial growth factor signaling pathway  
Ontology : EGO-EBIprenylated protein tyrosine phosphatase activity  nucleus  cytoplasm  early endosome  plasma membrane  Notch signaling pathway  protein tyrosine/serine/threonine phosphatase activity  peptidyl-tyrosine dephosphorylation  peptidyl-tyrosine dephosphorylation  positive regulation of vascular permeability  endothelial cell migration  regulation of vascular endothelial growth factor signaling pathway  
NDEx Network
Atlas of Cancer Signalling NetworkPTP4A3
Wikipedia pathwaysPTP4A3
Orthology - Evolution
OrthoDB11156
GeneTree (enSembl)ENSG00000184489
Phylogenetic Trees/Animal Genes : TreeFamPTP4A3
Homologs : HomoloGenePTP4A3
Homology/Alignments : Family Browser (UCSC)PTP4A3
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerPTP4A3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTP4A3
dbVarPTP4A3
ClinVarPTP4A3
1000_GenomesPTP4A3 
Exome Variant ServerPTP4A3
ExAC (Exome Aggregation Consortium)PTP4A3 (select the gene name)
SNP (GeneSNP Utah)PTP4A3
SNP : HGBasePTP4A3
Genetic variants : HAPMAPPTP4A3
Genomic Variants (DGV)PTP4A3 [DGVbeta]
Mutations
ICGC Data PortalPTP4A3 
TCGA Data PortalPTP4A3 
Broad Tumor PortalPTP4A3
OASIS PortalPTP4A3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTP4A3 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PTP4A3
DgiDB (Drug Gene Interaction Database)PTP4A3
DoCM (Curated mutations)PTP4A3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PTP4A3 (select a term)
intoGenPTP4A3
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)8:142431488-142442554
CONAN: Copy Number AnalysisPTP4A3 
Mutations and Diseases : HGMDPTP4A3
OMIM606449   
MedgenPTP4A3
Genetic Testing Registry PTP4A3
NextProtO75365 [Medical]
TSGene11156
GENETestsPTP4A3
Huge Navigator PTP4A3 [HugePedia]  PTP4A3 [HugeCancerGEM]
snp3D : Map Gene to Disease11156
BioCentury BCIQPTP4A3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11156
Chemical/Pharm GKB GenePA33979
Clinical trialPTP4A3
Miscellaneous
canSAR (ICR)PTP4A3 (select the gene name)
Probes
Litterature
PubMed118 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePTP4A3
GoPubMedPTP4A3
iHOPPTP4A3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Apr 16 18:00:49 CEST 2016

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