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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret jlhuret@AtlasGeneticsOncology.org
Donations are also welcome
If each casual visitor gives 3 Euros or Dollars, the Atlas is saved in a week !
If each professional gives 100 Euros or Dollars once a year (now), the Atlas is saved in 2 weeks !
Don't let the Atlas imminent demise
Note: we send fiscal receipts for donations equal or above 50 Euros or Dollars

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PTP4A3 (protein tyrosine phosphatase type IVA, member 3)

Identity

Other namesPRL-3
PRL-R
PRL3
HGNC (Hugo) PTP4A3
LocusID (NCBI) 11156
Location 8q24.3
Location_base_pair Starts at 142431488 and ends at 142442554 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PTP4A3   9636
Cards
Entrez_Gene (NCBI)PTP4A3  11156  protein tyrosine phosphatase type IVA, member 3
GeneCards (Weizmann)PTP4A3
Ensembl hg19 (Hinxton)ENSG00000184489 [Gene_View]  chr8:142431488-142442554 [Contig_View]  PTP4A3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000184489 [Gene_View]  chr8:142431488-142442554 [Contig_View]  PTP4A3 [Vega]
ICGC DataPortalENSG00000184489
cBioPortalPTP4A3
AceView (NCBI)PTP4A3
Genatlas (Paris)PTP4A3
WikiGenes11156
SOURCE (Princeton)PTP4A3
Genomic and cartography
GoldenPath hg19 (UCSC)PTP4A3  -     chr8:142431488-142442554 +  8q24.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PTP4A3  -     8q24.3   [Description]    (hg38-Dec_2013)
EnsemblPTP4A3 - 8q24.3 [CytoView hg19]  PTP4A3 - 8q24.3 [CytoView hg38]
Mapping of homologs : NCBIPTP4A3 [Mapview hg19]  PTP4A3 [Mapview hg38]
OMIM606449   
Gene and transcription
Genbank (Entrez)AF041434 AI742376 AJ276554 AK311257 BC003105
RefSeq transcript (Entrez)NM_007079 NM_032611
RefSeq genomic (Entrez)NC_000008 NC_018919 NT_008046 NT_187574 NW_004929340
Consensus coding sequences : CCDS (NCBI)PTP4A3
Cluster EST : UnigeneHs.744870 [ NCBI ]
CGAP (NCI)Hs.744870
Alternative Splicing : Fast-db (Paris)GSHG0033563
Alternative Splicing GalleryENSG00000184489
Gene ExpressionPTP4A3 [ NCBI-GEO ]     PTP4A3 [ SEEK ]   PTP4A3 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75365 (Uniprot)
NextProtO75365  [Medical]
With graphics : InterProO75365
Splice isoforms : SwissVarO75365 (Swissvar)
Catalytic activity : Enzyme3.1.3.48 [ Enzyme-Expasy ]   3.1.3.483.1.3.48 [ IntEnz-EBI ]   3.1.3.48 [ BRENDA ]   3.1.3.48 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)TYR_PHOSPHATASE_2 (PS50056)   
Domains : Interpro (EBI)Prot-tyrosine_phosphatase-like    Tyr/Dual-sp_Pase    Tyr_Pase_rcpt/non-rcpt   
Related proteins : CluSTrO75365
Domain families : Pfam (Sanger)Y_phosphatase (PF00102)   
Domain families : Pfam (NCBI)pfam00102   
DMDM Disease mutations11156
Blocks (Seattle)O75365
PDB (SRS)1R6H    1V3A    2MBC   
PDB (PDBSum)1R6H    1V3A    2MBC   
PDB (IMB)1R6H    1V3A    2MBC   
PDB (RSDB)1R6H    1V3A    2MBC   
Human Protein AtlasENSG00000184489
Peptide AtlasO75365
HPRD05922
IPIIPI00289328   IPI00026647   IPI00217075   IPI00983444   IPI00982778   
Protein Interaction databases
DIP (DOE-UCLA)O75365
IntAct (EBI)O75365
FunCoupENSG00000184489
BioGRIDPTP4A3
IntegromeDBPTP4A3
STRING (EMBL)PTP4A3
Ontologies - Pathways
QuickGOO75365
Ontology : AmiGOprenylated protein tyrosine phosphatase activity  early endosome  plasma membrane  peptidyl-tyrosine dephosphorylation  peptidyl-tyrosine dephosphorylation  endothelial cell migration  
Ontology : EGO-EBIprenylated protein tyrosine phosphatase activity  early endosome  plasma membrane  peptidyl-tyrosine dephosphorylation  peptidyl-tyrosine dephosphorylation  endothelial cell migration  
Protein Interaction DatabasePTP4A3
DoCM (Curated mutations)PTP4A3
Wikipedia pathwaysPTP4A3
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerPTP4A3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTP4A3
dbVarPTP4A3
ClinVarPTP4A3
1000_GenomesPTP4A3 
Exome Variant ServerPTP4A3
SNP (GeneSNP Utah)PTP4A3
SNP : HGBasePTP4A3
Genetic variants : HAPMAPPTP4A3
Genomic Variants (DGV)PTP4A3 [DGVbeta]
Mutations
ICGC Data PortalENSG00000184489 
Somatic Mutations in Cancer : COSMICPTP4A3 
CONAN: Copy Number AnalysisPTP4A3 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)8:142431488-142442554
Mutations and Diseases : HGMDPTP4A3
OMIM606449   
MedgenPTP4A3
NextProtO75365 [Medical]
GENETestsPTP4A3
Disease Genetic AssociationPTP4A3
Huge Navigator PTP4A3 [HugePedia]  PTP4A3 [HugeCancerGEM]
snp3D : Map Gene to Disease11156
DGIdb (Drug Gene Interaction db)PTP4A3
General knowledge
Homologs : HomoloGenePTP4A3
Homology/Alignments : Family Browser (UCSC)PTP4A3
Phylogenetic Trees/Animal Genes : TreeFamPTP4A3
Chemical/Protein Interactions : CTD11156
Chemical/Pharm GKB GenePA33979
Clinical trialPTP4A3
Cancer Resource (Charite)ENSG00000184489
Other databases
Probes
Litterature
PubMed115 Pubmed reference(s) in Entrez
CoreMinePTP4A3
GoPubMedPTP4A3
iHOPPTP4A3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Mar 28 17:03:30 CET 2015

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