PTPMT1 (protein tyrosine phosphatase mitochondrial 1)

2013-08-01  

Identity

HGNC
PTPMT1
LOCATION
11p11.2
LOCUSID
114971
ALIAS
DUSP23,MOSP,PLIP,PNAS-129
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 114971
MIM: 609538
HGNC: 26965
Ensembl: ENSG00000110536

Variants:

dbSNP: 114971
ClinVar: 114971
TCGA: ENSG00000110536
COSMIC: PTPMT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110536ENST00000326656Q8WUK0
ENSG00000110536ENST00000326674Q8WUK0
ENSG00000110536ENST00000426530Q8WUK0
ENSG00000110536ENST00000534775E9PQM0

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
Glycerophospholipid biosynthesisREACTOMER-HSA-1483206
Synthesis of PGREACTOMER-HSA-1483148

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
233265112013Downregulation of the mitochondrial phosphatase PTPMT1 is sufficient to promote cancer cell death.10
304290882018SRSF1 modulates PTPMT1 alternative splicing to regulate lung cancer cell radioresistance.5
247099862014The pseudophosphatase MK-STYX physically and genetically interacts with the mitochondrial phosphatase PTPMT1.4
268988022016Ptpmt1 induced by HIF-2α regulates the proliferation and glucose metabolism in erythroleukemia cells.3

Citation

Dessen P

PTPMT1 (protein tyrosine phosphatase mitochondrial 1)

Atlas Genet Cytogenet Oncol Haematol. 2013-08-01

Online version: http://atlasgeneticsoncology.org/gene/53737/ptpmt1