Identity
HGNC
LOCATION
18p11.21
LOCUSID
ALIAS
PTN2,PTPT,TC-PTP,TCELLPTP,TCPTP
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5771
MIM: 176887
HGNC: 9650
Ensembl: ENSG00000175354
Variants:
dbSNP: 5771
ClinVar: 5771
TCGA: ENSG00000175354
COSMIC: PTPN2
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38379221 | 2024 | PTPN2 inhibits the proliferation of psoriatic keratinocytes by dephosphorylation of STAT3. | 0 |
| 39028869 | 2024 | Haploinsufficiency in PTPN2 leads to early-onset systemic autoimmunity from Evans syndrome to lupus. | 0 |
| 38379221 | 2024 | PTPN2 inhibits the proliferation of psoriatic keratinocytes by dephosphorylation of STAT3. | 0 |
| 39028869 | 2024 | Haploinsufficiency in PTPN2 leads to early-onset systemic autoimmunity from Evans syndrome to lupus. | 0 |
| 34420044 | 2022 | Loss of protein tyrosine phosphatase non-receptor type 2 reduces IL-4-driven alternative macrophage activation. | 6 |
| 34806245 | 2022 | Structural characterization of a pathogenic mutant of human protein tyrosine phosphatase PTPN2 (Cys216Gly) that causes very early onset autoimmune enteropathy. | 5 |
| 35013194 | 2022 | The catalytic activity of TCPTP is auto-regulated by its intrinsically disordered tail and activated by Integrin alpha-1. | 17 |
| 35044456 | 2022 | PTPN2 Regulates the Interferon Signaling and Endoplasmic Reticulum Stress Response in Pancreatic β-Cells in Autoimmune Diabetes. | 7 |
| 35154122 | 2022 | PTPN2, A Key Predictor of Prognosis for Pancreatic Adenocarcinoma, Significantly Regulates Cell Cycles, Apoptosis, and Metastasis. | 8 |
| 35196085 | 2022 | PTPN2 elicits cell autonomous and non-cell autonomous effects on antitumor immunity in triple-negative breast cancer. | 14 |
| 35680018 | 2022 | The first association study of Protein Tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2) gene polymorphisms in Malaysian patients with Crohn's disease. | 0 |
| 36077422 | 2022 | PTPN2 in the Immunity and Tumor Immunotherapy: A Concise Review. | 5 |
| 36497105 | 2022 | Stem-Cell-Derived β-Like Cells with a Functional PTPN2 Knockout Display Increased Immunogenicity. | 3 |
| 34420044 | 2022 | Loss of protein tyrosine phosphatase non-receptor type 2 reduces IL-4-driven alternative macrophage activation. | 6 |
| 34806245 | 2022 | Structural characterization of a pathogenic mutant of human protein tyrosine phosphatase PTPN2 (Cys216Gly) that causes very early onset autoimmune enteropathy. | 5 |
Citation
Dessen P
PTPN2 (protein tyrosine phosphatase non-receptor type 2)
Atlas Genet Cytogenet Oncol Haematol. 2003-11-01
Online version: http://atlasgeneticsoncology.org/gene/41915/ptpn2
