Identity
HGNC
LOCATION
1p13.2
LOCUSID
ALIAS
LYP,LYP1,LYP2,PEP,PTPN22.5,PTPN22.6,PTPN8
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 26191
MIM: 600716
HGNC: 9652
Ensembl: ENSG00000134242
Variants:
dbSNP: 26191
ClinVar: 26191
TCGA: ENSG00000134242
COSMIC: PTPN22
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38112398 | 2024 | Increased expression of protein tyrosine phosphatase nonreceptor type 22 alters early T-cell receptor signaling and differentiation of CD4(+) T cells in chronic heart failure. | 1 |
| 38777143 | 2024 | A novel gain-of-function phosphorylation site modulates PTPN22 inhibition of TCR signaling. | 0 |
| 38112398 | 2024 | Increased expression of protein tyrosine phosphatase nonreceptor type 22 alters early T-cell receptor signaling and differentiation of CD4(+) T cells in chronic heart failure. | 1 |
| 38777143 | 2024 | A novel gain-of-function phosphorylation site modulates PTPN22 inhibition of TCR signaling. | 0 |
| 36811459 | 2023 | Molecular Dynamic Simulations Unravel the Underlying Impact of Missense Mutation in Autoimmunity Gene PTPN22 on Predisposition to Rheumatoid Arthritis. | 0 |
| 36961271 | 2023 | The association between PTPN22 C1858T gene polymorphism and type 1 diabetes mellitus: an Indonesian study. | 0 |
| 37061279 | 2023 | Relative CTLA-4, PTPN-22, and interleukin 37 mRNA expressions in patients with lupus nephritis. | 1 |
| 37315092 | 2023 | PTPN22 intron polymorphism rs1310182 (c.2054-852T>C) is associated with type 1 diabetes mellitus in patients of Armenian descent. | 0 |
| 37443055 | 2023 | Targeted inhibition of PTPN22 is a novel approach to alleviate osteogenic responses in aortic valve interstitial cells and aortic valve lesions in mice. | 2 |
| 37724526 | 2023 | DNA methylation differences within INS, PTPN22 and IL2RA promoters in lymphocyte subsets in children with type 1 diabetes and controls. | 0 |
| 37858140 | 2023 | CircPTPN22 modulates T-cell activation by sponging miR-4689 to regulate S1PR1 expression in patients with systemic lupus erythematosus. | 2 |
| 37893542 | 2023 | Association between PYTPN22 rs2476601, VEGF rs833070, TNFAIP3 rs6920220 Polymorphisms and Risk for Rheumatoid Arthritis in Early Undifferentiated Arthritis Patients: A Pilot Study. | 0 |
| 36811459 | 2023 | Molecular Dynamic Simulations Unravel the Underlying Impact of Missense Mutation in Autoimmunity Gene PTPN22 on Predisposition to Rheumatoid Arthritis. | 0 |
| 36961271 | 2023 | The association between PTPN22 C1858T gene polymorphism and type 1 diabetes mellitus: an Indonesian study. | 0 |
| 37061279 | 2023 | Relative CTLA-4, PTPN-22, and interleukin 37 mRNA expressions in patients with lupus nephritis. | 1 |
Citation
Dessen P
PTPN22 (protein tyrosine phosphatase non-receptor type 22)
Atlas Genet Cytogenet Oncol Haematol. 2012-03-01
Online version: http://atlasgeneticsoncology.org/gene/52604/ptpn22
