Identity
HGNC
LOCATION
3p21.31
LOCUSID
ALIAS
HD-PTP,HDPTP,NEDBASS,PTP-TD14
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 25930
MIM: 606584
HGNC: 14406
Ensembl: ENSG00000076201
Variants:
dbSNP: 25930
ClinVar: 25930
TCGA: ENSG00000076201
COSMIC: PTPN23
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000076201 | ENST00000265562 | Q9H3S7 |
| ENSG00000076201 | ENST00000456221 | C9JD91 |
| ENSG00000076201 | ENST00000602307 | R4GMM7 |
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38704135 | 2024 | PTPN23[Thr] variant reduces susceptibility and tumorigenesis in esophageal squamous cell carcinoma through dephosphorylation of EGFR. | 0 |
| 38704135 | 2024 | PTPN23[Thr] variant reduces susceptibility and tumorigenesis in esophageal squamous cell carcinoma through dephosphorylation of EGFR. | 0 |
| 37821451 | 2023 | PTPN23 ubiquitination by WDR4 suppresses EGFR and c-MET degradation to define a lung cancer therapeutic target. | 2 |
| 37821451 | 2023 | PTPN23 ubiquitination by WDR4 suppresses EGFR and c-MET degradation to define a lung cancer therapeutic target. | 2 |
| 34586919 | 2021 | Interactions of ubiquitin and CHMP5 with the V domain of HD-PTP reveals role for regulation of Vps4 ATPase. | 3 |
| 34586919 | 2021 | Interactions of ubiquitin and CHMP5 with the V domain of HD-PTP reveals role for regulation of Vps4 ATPase. | 3 |
| 31395947 | 2020 | Phenotype and mutation expansion of the PTPN23 associated disorder characterized by neurodevelopmental delay and structural brain abnormalities. | 9 |
| 31395947 | 2020 | Phenotype and mutation expansion of the PTPN23 associated disorder characterized by neurodevelopmental delay and structural brain abnormalities. | 9 |
| 29899372 | 2018 | Developmental epileptic encephalopathy with hypomyelination and brain atrophy associated with PTPN23 variants affecting the assembly of UsnRNPs. | 6 |
| 29899372 | 2018 | Developmental epileptic encephalopathy with hypomyelination and brain atrophy associated with PTPN23 variants affecting the assembly of UsnRNPs. | 6 |
| 28620046 | 2017 | Role of ESCRT component HD-PTP/PTPN23 in cancer. | 16 |
| 29066500 | 2017 | Suppression of protein tyrosine phosphatase N23 predisposes to breast tumorigenesis via activation of FYN kinase. | 24 |
| 29090338 | 2017 | Mutations of PTPN23 in developmental and epileptic encephalopathy. | 8 |
| 28620046 | 2017 | Role of ESCRT component HD-PTP/PTPN23 in cancer. | 16 |
| 29066500 | 2017 | Suppression of protein tyrosine phosphatase N23 predisposes to breast tumorigenesis via activation of FYN kinase. | 24 |
Citation
Dessen P
PTPN23 (protein tyrosine phosphatase non-receptor type 23)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/41917/ptpn23
