Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5774
MIM: 176877
HGNC: 9655
Ensembl: ENSG00000070159
Variants:
dbSNP: 5774
ClinVar: 5774
TCGA: ENSG00000070159
COSMIC: PTPN3
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000070159 | ENST00000262539 | J3KN34 |
| ENSG00000070159 | ENST00000374541 | P26045 |
| ENSG00000070159 | ENST00000412145 | P26045 |
| ENSG00000070159 | ENST00000446349 | P26045 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Signal Transduction | REACTOME | R-HSA-162582 |
| Signaling by EGFR | REACTOME | R-HSA-177929 |
| EGFR downregulation | REACTOME | R-HSA-182971 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38173048 | 2024 | Identification and verification of PTPN3 as a novel biomarker in predicting cancer prognosis, immunity, and immunotherapeutic efficacy. | 0 |
| 38297883 | 2024 | Inhibition of PTPN3 Expressed in Activated Lymphocytes Enhances the Antitumor Effects of Anti-PD-1 Therapy in Head and Neck Cancer, Especially in Hypoxic Environments. | 0 |
| 38173048 | 2024 | Identification and verification of PTPN3 as a novel biomarker in predicting cancer prognosis, immunity, and immunotherapeutic efficacy. | 0 |
| 38297883 | 2024 | Inhibition of PTPN3 Expressed in Activated Lymphocytes Enhances the Antitumor Effects of Anti-PD-1 Therapy in Head and Neck Cancer, Especially in Hypoxic Environments. | 0 |
| 35641270 | 2022 | PTPN3 Could Βe a Therapeutic Target of Pancreatic Cancer. | 0 |
| 35641270 | 2022 | PTPN3 Could Βe a Therapeutic Target of Pancreatic Cancer. | 0 |
| 33441627 | 2021 | Molecular basis of the interaction of the human tyrosine phosphatase PTPN3 with the hepatitis B virus core protein. | 9 |
| 33441627 | 2021 | Molecular basis of the interaction of the human tyrosine phosphatase PTPN3 with the hepatitis B virus core protein. | 9 |
| 31706106 | 2020 | PTPN3 suppresses the proliferation and correlates with favorable prognosis of perihilar cholangiocarcinoma by inhibiting AKT phosphorylation. | 3 |
| 31972307 | 2020 | MicroRNA-574-5p in gastric cancer cells promotes angiogenesis by targeting protein tyrosine phosphatase non-receptor type 3 (PTPN3). | 16 |
| 32169891 | 2020 | PTPN3 Inhibits the Growth and Metastasis of Clear Cell Renal Cell Carcinoma via Inhibition of PI3K/AKT Signaling. | 11 |
| 33137650 | 2020 | NFκB and TGFβ contribute to the expression of PTPN3 in activated human lymphocytes. | 2 |
| 31706106 | 2020 | PTPN3 suppresses the proliferation and correlates with favorable prognosis of perihilar cholangiocarcinoma by inhibiting AKT phosphorylation. | 3 |
| 31972307 | 2020 | MicroRNA-574-5p in gastric cancer cells promotes angiogenesis by targeting protein tyrosine phosphatase non-receptor type 3 (PTPN3). | 16 |
| 32169891 | 2020 | PTPN3 Inhibits the Growth and Metastasis of Clear Cell Renal Cell Carcinoma via Inhibition of PI3K/AKT Signaling. | 11 |
Citation
Dessen P
PTPN3 (protein tyrosine phosphatase non-receptor type 3)
Atlas Genet Cytogenet Oncol Haematol. 2003-11-01
Online version: http://atlasgeneticsoncology.org/gene/41918/ptpn3
