PTPRE (protein tyrosine phosphatase receptor type E)

2003-12-01  

Identity

HGNC
PTPRE
LOCATION
10q26.2
LOCUSID
5791
ALIAS
HPTPE,PTPE,R-PTP-EPSILON
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5791
MIM: 600926
HGNC: 9669
Ensembl: ENSG00000132334

Variants:

dbSNP: 5791
ClinVar: 5791
TCGA: ENSG00000132334
COSMIC: PTPRE

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132334ENST00000254667P23469
ENSG00000132334ENST00000306042P23469
ENSG00000132334ENST00000442830Q5VWH6
ENSG00000132334ENST00000455661Q5VWH5
ENSG00000132334ENST00000467366S4R3X3
ENSG00000132334ENST00000471218S4R3B0
ENSG00000132334ENST00000479896S4R2Y5
ENSG00000132334ENST00000495530S4R448

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
202019262010Human variation in alcohol response is influenced by variation in neuronal signaling genes.45
123765452002Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases.22
128610302003Dimerization in vivo and inhibition of the nonreceptor form of protein tyrosine phosphatase epsilon.17
217344002011Attempted replication of 50 reported asthma risk genes identifies a SNP in RAD50 as associated with childhood atopic asthma.16
127543012003Protein tyrosine phosphatase epsilon inhibits signaling by mitogen-activated protein kinases.12
121214392002Expression of human protein tyrosine phosphatase epsilon in leucocytes: a potential ERK pathway-regulating phosphatase.10
186827982008Genes to diseases (G2D) computational method to identify asthma candidate genes.10
221170742012Epidermal growth factor receptor (EGFR)-mediated positive feedback of protein-tyrosine phosphatase epsilon (PTPepsilon) on ERK1/2 and AKT protein pathways is required for survival of human breast cancer cells.9

Citation

Dessen P

PTPRE (protein tyrosine phosphatase receptor type E)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/41928/ptpre